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dc.contributor.authorMoore, James Ven
dc.contributor.authorDelic, Julian Ien
dc.contributor.authorBentley, Janet Een
dc.date.accessioned2010-12-07T17:18:12Z
dc.date.available2010-12-07T17:18:12Z
dc.date.issued1985-08
dc.identifier.citationDifferential effect of i.p.- and i.v.-injected adriamycin on the clonogenic spermatogonia of murine testis. 1985, 21 (8):991-4 Eur J Cancer Clin Oncolen
dc.identifier.issn0277-5379
dc.identifier.pmid4043182
dc.identifier.doi10.1016/0277-5379(85)90120-8
dc.identifier.urihttp://hdl.handle.net/10541/117348
dc.description.abstractThe response of murine clonogenic spermatogonia has been measured after intraperitoneal or intravenous injections of adriamycin (ADR). When measured over the whole testis, the survival curve for regenerating tubules after i.p. ADR had a 10-15% lower LD37 dose (that dose which sterilises 37% of tubules) but a two-fold higher average D0 for the clonogenic cells than that for i.v. ADR. Survival was then measured in concentric zones of these equatorial sections of testis. For i.v. injection survival parameters varied little between zones in the centre of the testis and zones adjoining the testicular capsule. In contrast, for i.p. ADR central zones had a 40% higher LD37 but the same D0 as for i.v. ADR, while peripheral zones had LD37s as little as 35% of the i.v. figure and mean D0s 2-3 times higher. Pharmacokinetic considerations that might lead to these differences in clonogenic response are discussed.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCell Survival
dc.subject.meshColony-Forming Units Assay
dc.subject.meshDoxorubicin
dc.subject.meshInjections, Intraperitoneal
dc.subject.meshInjections, Intravenous
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshSeminiferous Tubules
dc.subject.meshSpermatogonia
dc.subject.meshSpermatozoa
dc.subject.meshTestis
dc.titleDifferential effect of i.p.- and i.v.-injected adriamycin on the clonogenic spermatogonia of murine testis.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, U.K.en
dc.identifier.journalEuropean Journal of Cancer & Clinical Oncologyen
html.description.abstractThe response of murine clonogenic spermatogonia has been measured after intraperitoneal or intravenous injections of adriamycin (ADR). When measured over the whole testis, the survival curve for regenerating tubules after i.p. ADR had a 10-15% lower LD37 dose (that dose which sterilises 37% of tubules) but a two-fold higher average D0 for the clonogenic cells than that for i.v. ADR. Survival was then measured in concentric zones of these equatorial sections of testis. For i.v. injection survival parameters varied little between zones in the centre of the testis and zones adjoining the testicular capsule. In contrast, for i.p. ADR central zones had a 40% higher LD37 but the same D0 as for i.v. ADR, while peripheral zones had LD37s as little as 35% of the i.v. figure and mean D0s 2-3 times higher. Pharmacokinetic considerations that might lead to these differences in clonogenic response are discussed.


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