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    Differential effect of i.p.- and i.v.-injected adriamycin on the clonogenic spermatogonia of murine testis.

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    Authors
    Moore, James V
    Delic, Julian I
    Bentley, Janet E
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, U.K.
    Issue Date
    1985-08
    
    Metadata
    Show full item record
    Abstract
    The response of murine clonogenic spermatogonia has been measured after intraperitoneal or intravenous injections of adriamycin (ADR). When measured over the whole testis, the survival curve for regenerating tubules after i.p. ADR had a 10-15% lower LD37 dose (that dose which sterilises 37% of tubules) but a two-fold higher average D0 for the clonogenic cells than that for i.v. ADR. Survival was then measured in concentric zones of these equatorial sections of testis. For i.v. injection survival parameters varied little between zones in the centre of the testis and zones adjoining the testicular capsule. In contrast, for i.p. ADR central zones had a 40% higher LD37 but the same D0 as for i.v. ADR, while peripheral zones had LD37s as little as 35% of the i.v. figure and mean D0s 2-3 times higher. Pharmacokinetic considerations that might lead to these differences in clonogenic response are discussed.
    Citation
    Differential effect of i.p.- and i.v.-injected adriamycin on the clonogenic spermatogonia of murine testis. 1985, 21 (8):991-4 Eur J Cancer Clin Oncol
    Journal
    European Journal of Cancer & Clinical Oncology
    URI
    http://hdl.handle.net/10541/117348
    DOI
    10.1016/0277-5379(85)90120-8
    PubMed ID
    4043182
    Type
    Article
    Language
    en
    ISSN
    0277-5379
    ae974a485f413a2113503eed53cd6c53
    10.1016/0277-5379(85)90120-8
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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