Relationships between chromosome damage, cell cycle delay and cell killing induced by bleomycin or X-rays.
| dc.contributor.author | Scott, David | |
| dc.contributor.author | Zampetti-Bosseler, F | |
| dc.date.accessioned | 2010-12-07T16:54:21Z | |
| dc.date.available | 2010-12-07T16:54:21Z | |
| dc.date.issued | 1985-08 | |
| dc.identifier.citation | Relationships between chromosome damage, cell cycle delay and cell killing induced by bleomycin or X-rays. 1985, 151 (1):83-8 Mutat Res | en |
| dc.identifier.issn | 0027-5107 | |
| dc.identifier.pmid | 2410787 | |
| dc.identifier.doi | 10.1016/0165-7992(85)90089-2 | |
| dc.identifier.uri | http://hdl.handle.net/10541/117345 | |
| dc.description.abstract | The extent of mitotic delay and chromosome aberration induction by X-rays and bleomycin has been compared in normal human foetal fibroblasts at doses giving approximately equal levels of cell killing, assayed as colony-forming ability. Bleomycin induced much less G2 delay and chromosome damage than X-rays. We conclude that the major mechanism of cell killing by bleomycin does not involve chromosome damage but the cells pass through a number of division cycles before dying and a common DNA lesion is involved in G2 delay and chromosome damage. | |
| dc.language.iso | en | en |
| dc.subject.mesh | Bleomycin | |
| dc.subject.mesh | Cell Cycle | |
| dc.subject.mesh | Cell Survival | |
| dc.subject.mesh | Chromosome Aberrations | |
| dc.subject.mesh | Chromosomes | |
| dc.subject.mesh | Extrachromosomal Inheritance | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Mitosis | |
| dc.subject.mesh | X-Rays | |
| dc.title | Relationships between chromosome damage, cell cycle delay and cell killing induced by bleomycin or X-rays. | en |
| dc.type | Article | en |
| dc.contributor.department | Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX Great Britain | en |
| dc.identifier.journal | Mutation Research | en |
| html.description.abstract | The extent of mitotic delay and chromosome aberration induction by X-rays and bleomycin has been compared in normal human foetal fibroblasts at doses giving approximately equal levels of cell killing, assayed as colony-forming ability. Bleomycin induced much less G2 delay and chromosome damage than X-rays. We conclude that the major mechanism of cell killing by bleomycin does not involve chromosome damage but the cells pass through a number of division cycles before dying and a common DNA lesion is involved in G2 delay and chromosome damage. |