Relationships between chromosome damage, cell cycle delay and cell killing induced by bleomycin or X-rays.
AffiliationPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX Great Britain
MetadataShow full item record
AbstractThe extent of mitotic delay and chromosome aberration induction by X-rays and bleomycin has been compared in normal human foetal fibroblasts at doses giving approximately equal levels of cell killing, assayed as colony-forming ability. Bleomycin induced much less G2 delay and chromosome damage than X-rays. We conclude that the major mechanism of cell killing by bleomycin does not involve chromosome damage but the cells pass through a number of division cycles before dying and a common DNA lesion is involved in G2 delay and chromosome damage.
CitationRelationships between chromosome damage, cell cycle delay and cell killing induced by bleomycin or X-rays. 1985, 151 (1):83-8 Mutat Res