Reactions of the semiquinone free radicals of anti-tumour agents with oxygen and iron complexes.
| dc.contributor.author | Butler, John | |
| dc.contributor.author | Hoey, Brigid M | |
| dc.contributor.author | Swallow, A John | |
| dc.date.accessioned | 2010-12-07T17:14:20Z | |
| dc.date.available | 2010-12-07T17:14:20Z | |
| dc.date.issued | 1985-03-11 | |
| dc.identifier.citation | Reactions of the semiquinone free radicals of anti-tumour agents with oxygen and iron complexes. 1985, 182 (1):95-8 FEBS Lett | en |
| dc.identifier.issn | 0014-5793 | |
| dc.identifier.pmid | 3918891 | |
| dc.identifier.doi | 10.1016/0014-5793(85)81161-3 | |
| dc.identifier.uri | http://hdl.handle.net/10541/117337 | |
| dc.description.abstract | The rates of reaction of the semiquinone radicals of adriamycin and mitomycin C with oxygen and several iron (III) complexes have been determined. These rates have been used to explain enhanced free radical damage produced by semiquinone radicals in a model system and to assess the feasibility of these types of reactions occurring in hypoxic cells. | |
| dc.language.iso | en | en |
| dc.subject.mesh | Benzoquinones | |
| dc.subject.mesh | Chemical Phenomena | |
| dc.subject.mesh | Chemistry | |
| dc.subject.mesh | Doxorubicin | |
| dc.subject.mesh | Ferric Compounds | |
| dc.subject.mesh | Iron | |
| dc.subject.mesh | Mitomycin | |
| dc.subject.mesh | Mitomycins | |
| dc.subject.mesh | Oxygen | |
| dc.subject.mesh | Quinones | |
| dc.title | Reactions of the semiquinone free radicals of anti-tumour agents with oxygen and iron complexes. | en |
| dc.type | Article | en |
| dc.contributor.department | Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, England | en |
| dc.identifier.journal | FEBS Letters | en |
| html.description.abstract | The rates of reaction of the semiquinone radicals of adriamycin and mitomycin C with oxygen and several iron (III) complexes have been determined. These rates have been used to explain enhanced free radical damage produced by semiquinone radicals in a model system and to assess the feasibility of these types of reactions occurring in hypoxic cells. |