Reactions of the semiquinone free radicals of anti-tumour agents with oxygen and iron complexes.
AffiliationPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, England
MetadataShow full item record
AbstractThe rates of reaction of the semiquinone radicals of adriamycin and mitomycin C with oxygen and several iron (III) complexes have been determined. These rates have been used to explain enhanced free radical damage produced by semiquinone radicals in a model system and to assess the feasibility of these types of reactions occurring in hypoxic cells.
CitationReactions of the semiquinone free radicals of anti-tumour agents with oxygen and iron complexes. 1985, 182 (1):95-8 FEBS Lett