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dc.contributor.authorWright, E
dc.contributor.authorLorimore, S
dc.contributor.authorLord, Brian I
dc.date.accessioned2010-12-07T17:12:10Z
dc.date.available2010-12-07T17:12:10Z
dc.date.issued1985
dc.identifier.citationRegulators of stem cell proliferation in the haemopoietic tissues of W/Wv and S1/S1d mice. 1985, 9 (4):491-6 Leuk Resen
dc.identifier.issn0145-2126
dc.identifier.pmid3999801
dc.identifier.doi10.1016/0145-2126(85)90008-6
dc.identifier.urihttp://hdl.handle.net/10541/117336
dc.description.abstractThe presence of CFU-S proliferation stimulatory and inhibitory activities in the bone marrow and spleens of normal mice (+/+) and mice with mutations affecting the proliferative behaviour of stem cells (S1/S1d and W/Wv) has been investigated. S1/S1d and +/+ bone marrow and spleen contain virtually no detectable stimulator but the corresponding tissues from W/Wv mice are both strongly stimulatory. S1/S1d marrow in particular, but also +/+ marrow are strongly inhibitory whilst +/+ spleen, S1/S1d spleen, W/Wv marrow and W/Wv spleen all contain inhibitory activity but at a lower specific activity. The data are compatible with studies of cell and tissue grafts that have indicated an intrinsic haemopoietic stem cell defect in W/Wv mice and an extrinsic, microenvironmental defect in S1/S1d mice. It is suggested that they are also compatible with defective regulatory interactions between stem cells and regulator-producing cells and that the W and S1 loci may code for products involved in the production of, or response to, CFU-S proliferation regulators.
dc.language.isoenen
dc.subjectHaematopoietic Stem Cellsen
dc.subject.meshAnimals
dc.subject.meshBone Marrow Cells
dc.subject.meshCell Division
dc.subject.meshDNA
dc.subject.meshHematopoietic Stem Cells
dc.subject.meshMice
dc.subject.meshMice, Mutant Strains
dc.subject.meshPhenylhydrazines
dc.subject.meshSpleen
dc.titleRegulators of stem cell proliferation in the haemopoietic tissues of W/Wv and S1/S1d mice.en
dc.typeArticleen
dc.contributor.departmentDepartment of Anatomy and Experimental Pathology, University of St Andrewsen
dc.identifier.journalLeukemia Researchen
html.description.abstractThe presence of CFU-S proliferation stimulatory and inhibitory activities in the bone marrow and spleens of normal mice (+/+) and mice with mutations affecting the proliferative behaviour of stem cells (S1/S1d and W/Wv) has been investigated. S1/S1d and +/+ bone marrow and spleen contain virtually no detectable stimulator but the corresponding tissues from W/Wv mice are both strongly stimulatory. S1/S1d marrow in particular, but also +/+ marrow are strongly inhibitory whilst +/+ spleen, S1/S1d spleen, W/Wv marrow and W/Wv spleen all contain inhibitory activity but at a lower specific activity. The data are compatible with studies of cell and tissue grafts that have indicated an intrinsic haemopoietic stem cell defect in W/Wv mice and an extrinsic, microenvironmental defect in S1/S1d mice. It is suggested that they are also compatible with defective regulatory interactions between stem cells and regulator-producing cells and that the W and S1 loci may code for products involved in the production of, or response to, CFU-S proliferation regulators.


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