Regulators of stem cell proliferation in the haemopoietic tissues of W/Wv and S1/S1d mice.
Affiliation
Department of Anatomy and Experimental Pathology, University of St AndrewsIssue Date
1985
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The presence of CFU-S proliferation stimulatory and inhibitory activities in the bone marrow and spleens of normal mice (+/+) and mice with mutations affecting the proliferative behaviour of stem cells (S1/S1d and W/Wv) has been investigated. S1/S1d and +/+ bone marrow and spleen contain virtually no detectable stimulator but the corresponding tissues from W/Wv mice are both strongly stimulatory. S1/S1d marrow in particular, but also +/+ marrow are strongly inhibitory whilst +/+ spleen, S1/S1d spleen, W/Wv marrow and W/Wv spleen all contain inhibitory activity but at a lower specific activity. The data are compatible with studies of cell and tissue grafts that have indicated an intrinsic haemopoietic stem cell defect in W/Wv mice and an extrinsic, microenvironmental defect in S1/S1d mice. It is suggested that they are also compatible with defective regulatory interactions between stem cells and regulator-producing cells and that the W and S1 loci may code for products involved in the production of, or response to, CFU-S proliferation regulators.Citation
Regulators of stem cell proliferation in the haemopoietic tissues of W/Wv and S1/S1d mice. 1985, 9 (4):491-6 Leuk ResJournal
Leukemia ResearchDOI
10.1016/0145-2126(85)90008-6PubMed ID
3999801Type
ArticleLanguage
enISSN
0145-2126ae974a485f413a2113503eed53cd6c53
10.1016/0145-2126(85)90008-6