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    Regulators of stem cell proliferation in the haemopoietic tissues of W/Wv and S1/S1d mice.

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    Authors
    Wright, E
    Lorimore, S
    Lord, Brian I
    Affiliation
    Department of Anatomy and Experimental Pathology, University of St Andrews
    Issue Date
    1985
    
    Metadata
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    Abstract
    The presence of CFU-S proliferation stimulatory and inhibitory activities in the bone marrow and spleens of normal mice (+/+) and mice with mutations affecting the proliferative behaviour of stem cells (S1/S1d and W/Wv) has been investigated. S1/S1d and +/+ bone marrow and spleen contain virtually no detectable stimulator but the corresponding tissues from W/Wv mice are both strongly stimulatory. S1/S1d marrow in particular, but also +/+ marrow are strongly inhibitory whilst +/+ spleen, S1/S1d spleen, W/Wv marrow and W/Wv spleen all contain inhibitory activity but at a lower specific activity. The data are compatible with studies of cell and tissue grafts that have indicated an intrinsic haemopoietic stem cell defect in W/Wv mice and an extrinsic, microenvironmental defect in S1/S1d mice. It is suggested that they are also compatible with defective regulatory interactions between stem cells and regulator-producing cells and that the W and S1 loci may code for products involved in the production of, or response to, CFU-S proliferation regulators.
    Citation
    Regulators of stem cell proliferation in the haemopoietic tissues of W/Wv and S1/S1d mice. 1985, 9 (4):491-6 Leuk Res
    Journal
    Leukemia Research
    URI
    http://hdl.handle.net/10541/117336
    DOI
    10.1016/0145-2126(85)90008-6
    PubMed ID
    3999801
    Type
    Article
    Language
    en
    ISSN
    0145-2126
    ae974a485f413a2113503eed53cd6c53
    10.1016/0145-2126(85)90008-6
    Scopus Count
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