• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Survival curves for normal-tissue clonogens: a comparison of assessments using in vitro, transplantation, or in situ techniques.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Hendry, Jolyon H
    Affiliation
    Radiobiology Department, Immunology, Paterson Laboratories, Chistie Hospital and Holt Radium Institute, Manchester, M20 9BX, UK.
    Issue Date
    1985-01
    
    Metadata
    Show full item record
    Abstract
    A survey of survival curves in the literature, for clonogenic cells (clonogens) in normal tissues, highlights the following features: the sensitivity of some human and dog clonogens apparently is greater than that of their counterparts in mice and sheep, assessed in vitro. However, this should be interpreted with caution because of the possibility of cell selection and the ability to modify sensitivity markedly in some systems by variations in growth conditions; extrapolation numbers are in general higher when assessed in vivo than in vitro. This is due partly to the lack of measurements of repair of potentially-lethal damage using many assays in vitro. This feature increases the extrapolation number when measured using transplantation assays in vivo; epithelial clonogens in vivo demonstrate a remarkable similarity in sensitivity between tissues. The range is similar for clonogens assayed in situ or by transplantation, and this argues against the possibility that a resistant subpopulation may be selected in most assays in situ. It is emphasized from the comparisons that caution must be exercised in extrapolating results, obtained for clonogens assayed in vitro or by transplantation in vivo, to the situation in situ.
    Citation
    Survival curves for normal-tissue clonogens: a comparison of assessments using in vitro, transplantation, or in situ techniques. 1985, 47 (1):3-16 Int J Radiat Biol Relat Stud Phys Chem Med
    Journal
    International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
    URI
    http://hdl.handle.net/10541/117168
    PubMed ID
    3882586
    Type
    Article
    Language
    en
    ISSN
    0020-7616
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Dose-fractionation sensitivity of mouse kidney clonogens measured using different interfraction intervals and postirradiation assay times.
    • Authors: Jen YM, Hendry JH
    • Issue date: 1993 Feb
    • Repair of potentially lethal damage in rat mammary clonogens following irradiation in organoid culture.
    • Authors: Kamiya K, Kim ND, Gould MN, Clifton KH
    • Issue date: 1991 May
    • A critical appraisal of clonogenic survival assays in the evaluation of radiation damage to normal tissues.
    • Authors: Michalowski A
    • Issue date: 1984 Jan
    • Gamma-ray-induced cell killing and chromosome abnormalities in the bone marrow of p53-deficient mice.
    • Authors: Wang L, Cui Y, Lord BI, Roberts SA, Potten CS, Hendry JH, Scott D
    • Issue date: 1996 Sep
    • The effect of proliferative status and clonogen content on the response of mouse jejunal crypts to split-dose irradiation.
    • Authors: Thames HD, Ruifrok AC, Mason KA
    • Issue date: 1997 Feb
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.