• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Dose and time relationships in the endocrine response of the irradiated adult rat testis.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Delic, Julian I
    Hendry, Jolyon H
    Morris, Ian D
    Shalet, Stephen M
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, M20 9BX, UK.
    Issue Date
    1986
    
    Metadata
    Show full item record
    Abstract
    The dose- and time-dependent responses for the interstitial and tubular compartments in irradiated adult rat testes are described. Leydig cell dysfunction, as indicated by increased serum LH (to a maximum of 385% of control after 5 Gy) and decreased serum T (to a minimum of 30% of control after 10 Gy), was observed at 8 weeks postirradiation. Subsequent recovery of Leydig cell function was then observed, so that after 9 months serum T was normal but LH was still marginally elevated. The dysfunction, with a threshold of about 4 to 5 Gy, was associated with a loss of Leydig cells from the testis. Spermatogenic damage was observed; after doses of 3 Gy and above a marked dose-response was recorded as assessed by counts of tubule cross sections exhibiting spermatogenesis. Reduced serum levels of androgen binding protein indicated Sertoli cell dysfunction at 8 weeks after 3 Gy and above, with values of less than one half of those seen in the controls. Serum FSH also was elevated to between 150% and 200% of control, and after 9 months closely reflected androgen binding protein changes. Unlike the Leydig cell, no recovery with time was observed for this aspect of Sertoli cell function.
    Citation
    Dose and time relationships in the endocrine response of the irradiated adult rat testis., 7 (1):32-41 J Androl
    Journal
    Journal of Andrology
    URI
    http://hdl.handle.net/10541/117157
    PubMed ID
    3003018
    Type
    Article
    Language
    en
    ISSN
    0196-3635
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Sertoli cell-only syndrome produced by cold testicular ischemia.
    • Authors: Young GP, Goldstein M, Phillips DM, Sundaram K, Gunsalus GL, Bardin CW
    • Issue date: 1988 Mar
    • Leydig cell function in the pubertal rat following local testicular irradiation.
    • Authors: Delic JI, Hendry JH, Morris ID, Shalet SM
    • Issue date: 1986 Jan
    • Dose and time related responses of the irradiated prepubertal rat testis. I. Leydig cell function.
    • Authors: Delic JI, Hendry JH, Morris ID, Shalet SM
    • Issue date: 1985 Dec
    • Seminiferous epithelial function in the pubertal rat following local testicular irradiation.
    • Authors: Delic JI, Hendry JH, Morris ID, Shalet SM
    • Issue date: 1986 Jan
    • Evaluation of the relative importance of endocrine and paracrine factors in control of the levels of inhibin in testicular interstitial fluid.
    • Authors: Sharpe RM, Maddocks S
    • Issue date: 1989 Aug
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.