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    The extracellular matrix of human amniotic epithelium: ultrastructure, composition and deposition.

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    Authors
    Aplin, J
    Campbell, S
    Allen, Terence D
    Affiliation
    University of Manchester, St Mary's Hospital, Manchester M13 0JH, UK.
    Issue Date
    1985-11
    
    Metadata
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    Abstract
    Ultrastructural comparisons have been made between human amnion extracellular matrix in tissue and cell culture. Immunochemical analysis of matrix deposited by monolayers of cultured amnion epithelial cells has also been undertaken. The basal cell surfaces are highly invaginated with an associated basal lamina that is more electron dense at the distal tips of basal cell processes where hemidesmosomes are frequent. Immediately below the lamina densa is a zone rich in collagen bundles. In the underlying stroma two types of fibril predominate, one striated of 50 nm diameter and one of 18 nm diameter. The observations suggest that at gestational term the epithelial cells are still active in the production of matrix. Secretion appears to occur into invaginations in the basal cell surface where a loosely organized mixture of stromal-type and basal laminal-type aggregates is formed. In culture on plastic, cells also deposit a mixture of basal laminal (type IV collagen + laminin) and stromal (collagens type I + III) components as well as fibronectin. However, segregation into a true basal lamina with underlying stroma does not occur in vitro, suggesting the need for an organized subcellular template to complete matrix morphogenesis. The in vitro and in vivo evidence suggest that the epithelium contributes to the subjacent dense collagenous zone as well as to the basal lamina.
    Citation
    The extracellular matrix of human amniotic epithelium: ultrastructure, composition and deposition. 1985, 79:119-36 J Cell Sci
    Journal
    Journal of Cell Science
    URI
    http://hdl.handle.net/10541/117092
    PubMed ID
    3914477
    Type
    Article
    Language
    en
    ISSN
    0021-9533
    Collections
    All Paterson Institute for Cancer Research

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