AffiliationChristie Hospital, Manchester
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AbstractNon-metastatic mesoblastic nephromas from four young children were shown to contain fibronectin but not laminin using an immunoperoxidase staining procedure. In contrast, one metastasising spindle celled sarcomatous tumour from a neonate was laminin positive. During embryogenesis primitive nephrogenic mesenchyme contains only fibronectin and no laminin; metanephric blastema (permanent kidney) is positive for laminin. The staining for fibronectin and laminin may help to ascertain the histogenesis of different types of renal tumour.
CitationMesoblastic nephroma contains fibronectin but lacks laminin. 1985, 38 (5):507-11 J Clin Pathol
JournalJournal of Clinical Pathology
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