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    Serial incidence of bone marrow GM-CFC prior to the development of acute non-lymphoblastic leukaemia in a child treated for non-Hodgkin's lymphoma.

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    Authors
    Haworth, Catherine
    Stevens, R
    Testa, Nydia G
    Affiliation
    Paterson Laboratories, Christie Hospital, Manchester, UK
    Issue Date
    1985-01
    
    Metadata
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    Abstract
    A child treated for NHL developed acute non-lymphoblastic leukaemia 27 months after stopping treatment. Serial in vitro bone marrow studies showed a normal incidence of GM-CFC following treatment. However, GM-CFC incidence dropped at least 15 months prior to the development of leukaemia. This was associated with an asymptomatic neutropenia but no disturbance of bone marrow morphology. It is concluded that sub-clinical disturbances of bone marrow function may play an important part in leukaemogenesis.
    Citation
    Serial incidence of bone marrow GM-CFC prior to the development of acute non-lymphoblastic leukaemia in a child treated for non-Hodgkin's lymphoma. 1985, 59 (1):79-84 Br J Haematol
    Journal
    British Journal of Haematology
    URI
    http://hdl.handle.net/10541/117076
    DOI
    10.1111/j.1365-2141.1985.tb02966.x
    PubMed ID
    3970853
    Type
    Article
    Language
    en
    ISSN
    0007-1048
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2141.1985.tb02966.x
    Scopus Count
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    All Paterson Institute for Cancer Research

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