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    The prognostic significance of mediastinal bulk in patients with stage IA-IVB Hodgkin's disease: a report from the Manchester Lymphoma Group.

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    Authors
    Anderson, Heather
    Jenkins, Jeremy P R
    Brigg, David J
    Deakin, David P
    Palmer, Michael K
    Todd, Ian D
    Crowther, Derek
    Affiliation
    Departments of Medical Oncology, Radiology, Radiotherapy and Medical Statistics, Christie Hospital, Manchester
    Issue Date
    1985-09
    
    Metadata
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    Abstract
    Three hundred and two previously untreated patients with Stage IA-IVB Hodgkin's disease were reviewed to determine the prognostic significance of mediastinal involvement. Mediastinal bulk disease was defined as either a maximal mediastinal width of 7.5 cm or more, or a ratio of the maximum width of mediastinal disease to the maximum chest diameter of greater than or equal to 0.33, or a ratio of the maximum width of mediastinal disease to the chest diameter at T5-T6 greater than or equal to 0.33, or as an area of mediastinal disease greater than or equal to 100 cm2. Bulk disease outside the chest was defined as a mass of lymph nodes measuring 5 cm or more in any axis. The presence of mediastinal bulk disease was of adverse prognostic significance for remission duration and survival in patients with Stage IA-IIB Hodgkin's disease, but for patients with more advanced disease the effect of mediastinal bulk on remission duration and survival was not statistically significant. The mediastinal bulk variable which most significantly related to prognosis was the ratio of the maximum mediastinal disease to the chest diameter at T5-T6.
    Citation
    The prognostic significance of mediastinal bulk in patients with stage IA-IVB Hodgkin's disease: a report from the Manchester Lymphoma Group. 1985, 36 (5):449-54 Clin Radiol
    Journal
    Clinical Radiology
    URI
    http://hdl.handle.net/10541/117071
    DOI
    10.1016/S0009-9260(85)80183-5
    PubMed ID
    4075707
    Type
    Article
    Language
    en
    ISSN
    0009-9260
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0009-9260(85)80183-5
    Scopus Count
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    All Christie Publications

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