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    Virus infections in immunocompromised patients: their importance and their management.

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    Authors
    Sutton, R
    Itzhaki, Ruth F
    Christophers, J
    Saldanha, J
    Gannicliffe, A
    Anderson, Heather
    Affiliation
    Department of Virology, Withington Hospital, Manchester M20 8LR
    Issue Date
    1985-02
    
    Metadata
    Show full item record
    Abstract
    Opportunistic viral infections were investigated in 156 adult patients admitted over one year to a medical oncology service: 35% of the total group and 65% of those with acute leukaemia experienced viral infections, 79% of which were with viruses of the herpes group. Surprisingly few enteric viruses were recovered. Reactivation of herpes simplex virus in the brains of these immunosuppressed patients was suggested by the demonstration by nucleic acid hybridization of herpes simplex virus DNA sequences in neurones and endothelial cells in patients with evidence of past infection with virus. Acyclovir was effective in therapy and prophylaxis. Twenty-three strains from 7 patients were tested for sensitivity to this antiviral: in 3 instances clinical resistance was observed but the strains were fully sensitive in vitro, as were all other strains tested.
    Citation
    Virus infections in immunocompromised patients: their importance and their management. 1985, 78 (2):100-5 J R Soc Med
    Journal
    Journal of the Royal Society of Medicine
    URI
    http://hdl.handle.net/10541/117067
    PubMed ID
    2983073
    Type
    Article
    Language
    en
    ISSN
    0141-0768
    Collections
    All Christie Publications

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