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dc.contributor.authorShalet, Stephen M
dc.contributor.authorHorner, A
dc.contributor.authorAhmed, S Rafeeq
dc.contributor.authorMorris-Jones, P
dc.date.accessioned2010-12-02T16:39:03Z
dc.date.available2010-12-02T16:39:03Z
dc.date.issued1985
dc.identifier.citationLeydig cell damage after testicular irradiation for lymphoblastic leukaemia. 1985, 13 (2):65-8 Med Pediatr Oncolen
dc.identifier.issn0098-1532
dc.identifier.pmid3920486
dc.identifier.doi10.1002/mpo.2950130204
dc.identifier.urihttp://hdl.handle.net/10541/116985
dc.description.abstractThe effect of testicular irradiation on Leydig cell function has been studied in a group of boys irradiated between 1 and 5 years earlier for a testicular relapse of acute lymphoblastic leukaemia. Six of the seven boys irradiated during prepubertal life had an absent testosterone response to HCG stimulation. Two of the four boys irradiated during puberty had an appropriate basal testosterone level, but the testosterone response to HCG stimulation was subnormal in three of the four. Abnormalities in gonadotrophin secretion consistent with testicular damage were noted in nine of the 11 boys. Evidence of severe Leydig cell damage was present irrespective of whether the boys were studied within 1 year or between 3 and 5 years after irradiation, suggesting that recovery is unlikely. Androgen replacement therapy has been started in four boys and will be required by the majority of the remainder to undergo normal pubertal development.
dc.language.isoenen
dc.subjectLymphoid Leukaemiaen
dc.subjectTesticular Canceren
dc.subject.meshAdolescent
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshChorionic Gonadotropin
dc.subject.meshFollicle Stimulating Hormone
dc.subject.meshGonadotropin-Releasing Hormone
dc.subject.meshHumans
dc.subject.meshLeukemia, Lymphoid
dc.subject.meshLeydig Cells
dc.subject.meshLuteinizing Hormone
dc.subject.meshMale
dc.subject.meshPuberty
dc.subject.meshRadiation Injuries
dc.subject.meshTesticular Neoplasms
dc.subject.meshTestosterone
dc.titleLeydig cell damage after testicular irradiation for lymphoblastic leukaemia.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospitalen
dc.identifier.journalMedical and Pediatric Oncologyen
html.description.abstractThe effect of testicular irradiation on Leydig cell function has been studied in a group of boys irradiated between 1 and 5 years earlier for a testicular relapse of acute lymphoblastic leukaemia. Six of the seven boys irradiated during prepubertal life had an absent testosterone response to HCG stimulation. Two of the four boys irradiated during puberty had an appropriate basal testosterone level, but the testosterone response to HCG stimulation was subnormal in three of the four. Abnormalities in gonadotrophin secretion consistent with testicular damage were noted in nine of the 11 boys. Evidence of severe Leydig cell damage was present irrespective of whether the boys were studied within 1 year or between 3 and 5 years after irradiation, suggesting that recovery is unlikely. Androgen replacement therapy has been started in four boys and will be required by the majority of the remainder to undergo normal pubertal development.


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