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dc.contributor.authorStewart, Alan L
dc.contributor.authorMargison, Jennifer M
dc.contributor.authorWilkinson, Peter M
dc.contributor.authorLucas, S
dc.date.accessioned2010-12-02T17:03:39Z
dc.date.available2010-12-02T17:03:39Z
dc.date.issued1985
dc.identifier.citationThe pharmacokinetics of 7-hydroxymethotrexate following medium-dose methotrexate therapy. 1985, 14 (2):165-7 Cancer Chemother Pharmacolen
dc.identifier.issn0344-5704
dc.identifier.pmid3971482
dc.identifier.doi10.1007/BF00434358
dc.identifier.urihttp://hdl.handle.net/10541/116972
dc.description.abstractAn unambiguous and specific HPLC assay was used to determine the pharmacokinetics of 7-hydroxymethotrexate (7-OHMTX) following the administration of moderate-dose methotrexate (MTX) 100 mg X m-2 to 37 patients with advanced head and neck cancer. There was marked interpatient variation but patient exposure to 7-OHMTX was considerable. There was, however, no correlation between the amount of 7-OHMTX produced and either tumour response or patient toxicity.
dc.language.isoenen
dc.subjectHead and Neck Canceren
dc.subject.meshChromatography, High Pressure Liquid
dc.subject.meshHead and Neck Neoplasms
dc.subject.meshHumans
dc.subject.meshKinetics
dc.subject.meshMethotrexate
dc.titleThe pharmacokinetics of 7-hydroxymethotrexate following medium-dose methotrexate therapy.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Pharmacology, CHristie Hospital & Holt Radium Institute, Withington, Manchester, M20 9BX, Englanden
dc.identifier.journalCancer Chemotherapy and Pharmacologyen
html.description.abstractAn unambiguous and specific HPLC assay was used to determine the pharmacokinetics of 7-hydroxymethotrexate (7-OHMTX) following the administration of moderate-dose methotrexate (MTX) 100 mg X m-2 to 37 patients with advanced head and neck cancer. There was marked interpatient variation but patient exposure to 7-OHMTX was considerable. There was, however, no correlation between the amount of 7-OHMTX produced and either tumour response or patient toxicity.


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