The pharmacokinetics of 7-hydroxymethotrexate following medium-dose methotrexate therapy.
AffiliationDepartment of Clinical Pharmacology, CHristie Hospital & Holt Radium Institute, Withington, Manchester, M20 9BX, England
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AbstractAn unambiguous and specific HPLC assay was used to determine the pharmacokinetics of 7-hydroxymethotrexate (7-OHMTX) following the administration of moderate-dose methotrexate (MTX) 100 mg X m-2 to 37 patients with advanced head and neck cancer. There was marked interpatient variation but patient exposure to 7-OHMTX was considerable. There was, however, no correlation between the amount of 7-OHMTX produced and either tumour response or patient toxicity.
CitationThe pharmacokinetics of 7-hydroxymethotrexate following medium-dose methotrexate therapy. 1985, 14 (2):165-7 Cancer Chemother Pharmacol
JournalCancer Chemotherapy and Pharmacology