Carcinomatous meningitis associated with infiltrating lobular carcinoma of the breast.
AffiliationCancer Research Campaign Department of Medical Oncology, University of Manchester, Christie Hospital and Holt Radium Institute, Manchester M20 9BX
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AbstractThe records of 365 patients with advanced carcinoma of the breast were examined to identify those with CNS involvement. Nineteen (5.2%) developed parenchymal cerebral deposits and 10 (2.7%) developed meningeal infiltration during the course of their disease. Parenchymal cerebral deposits were almost exclusively associated with infiltrating duct carcinoma (95%) and meningeal infiltration (carcinomatous meningitis) was almost exclusively associated with infiltrating lobular carcinoma. Meningeal infiltration occurred late in the course of advanced disease and was associated with diffuse involvement of the bone marrow and abdominal structures.
CitationCarcinomatous meningitis associated with infiltrating lobular carcinoma of the breast. 1985, 11 (1):33-6 Eur J Surg Oncol
JournalEuropean Journal of Surgical Oncology
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