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    A prospective study of the treatment of high-grade histology non-Hodgkin's lymphoma involving the gastrointestinal tract.

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    Authors
    Steward, William P
    Harris, Martin
    Wagstaff, John
    Scarffe, J Howard
    Deakin, David P
    Todd, Ian D
    Crowther, Derek
    Affiliation
    CRC Department of Medical Oncology and Departments of Histopathology and Radiotherapy, Christie Hospital, Wilmslow Road, Manchester, UK
    Issue Date
    1985-10
    
    Metadata
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    Abstract
    Thirty-six patients presenting with stage II-IV primary gastrointestinal non-Hodgkin's lymphoma of high-grade pathology were treated in a prospective study from 1975 to 1983 with combined modality therapy. A complete response rate of 56% was obtained and the overall 5-yr survival rate was 36%. The 5-yr relapse-free survival rate of the complete remitters was 79%. Multivariate analysis revealed that the remission achieved (P less than 0.001) and the completeness of primary surgery (P = 0.018) would reliably predict the duration of overall survival. The finding of diffuse histiocytic histology (Rappaport) predicted longer relapse-free survival. The majority of deaths were related to intra-abdominal complications and not to disseminated lymphoma. Gastrointestinal tract non-Hodgkin's lymphoma of high-grade pathology of all stages is curable with a combination of chemotherapy and radiotherapy following surgery to remove as much macroscopic disease as is possible.
    Citation
    A prospective study of the treatment of high-grade histology non-Hodgkin's lymphoma involving the gastrointestinal tract. 1985, 21 (10):1195-200 Eur J Cancer Clin Oncol
    Journal
    European Journal of Cancer & Clinical Oncology
    URI
    http://hdl.handle.net/10541/116919
    DOI
    10.1016/0277-5379(85)90015-X
    PubMed ID
    3841067
    Type
    Article
    Language
    en
    ISSN
    0277-5379
    ae974a485f413a2113503eed53cd6c53
    10.1016/0277-5379(85)90015-X
    Scopus Count
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