Sequential chemotherapy for advanced epithelial ovarian cancer: platinum combination cytoreduction followed by cyclophosphamide consolidation.
Affiliation
Cancer Research Campaign, Department of Medical Oncology and Department of Radiology, Christie Hospital and Holt Radium Institute, Wilmslow Rd., Manchester UKIssue Date
1985-12
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Thirty-six women with advanced epithelial ovarian cancer were treated with a combination of cisplatin, vinblastine and bleomycin followed by a consolidation regimen of intravenous cyclophosphamide. There was a 53% response rate in previously untreated patients with 25% complete clinical remissions. Sixteen per cent of previously untreated patients remain in a complete clinical remission of greater than 3 yr duration. In a multivariate analysis bulk tumor residuum was not a significant adverse factor in terms of survival, suggesting that intensive chemical cytoreduction followed by non-cross-resistant consolidation may overcome such prognostic variables.Citation
Sequential chemotherapy for advanced epithelial ovarian cancer: platinum combination cytoreduction followed by cyclophosphamide consolidation. 1985, 21 (12):1479-83 Eur J Cancer Clin OncolJournal
European Journal of Cancer & Clinical OncologyDOI
10.1016/0277-5379(85)90242-1PubMed ID
2420603Type
ArticleLanguage
enISSN
0277-5379ae974a485f413a2113503eed53cd6c53
10.1016/0277-5379(85)90242-1
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