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    Sequential chemotherapy for advanced epithelial ovarian cancer: platinum combination cytoreduction followed by cyclophosphamide consolidation.

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    Authors
    Lawton, Frank
    Blackledge, G
    Buckley, H
    Johnson, Richard J
    Kelly, K
    Crowther, Derek
    Affiliation
    Cancer Research Campaign, Department of Medical Oncology and Department of Radiology, Christie Hospital and Holt Radium Institute, Wilmslow Rd., Manchester UK
    Issue Date
    1985-12
    
    Metadata
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    Abstract
    Thirty-six women with advanced epithelial ovarian cancer were treated with a combination of cisplatin, vinblastine and bleomycin followed by a consolidation regimen of intravenous cyclophosphamide. There was a 53% response rate in previously untreated patients with 25% complete clinical remissions. Sixteen per cent of previously untreated patients remain in a complete clinical remission of greater than 3 yr duration. In a multivariate analysis bulk tumor residuum was not a significant adverse factor in terms of survival, suggesting that intensive chemical cytoreduction followed by non-cross-resistant consolidation may overcome such prognostic variables.
    Citation
    Sequential chemotherapy for advanced epithelial ovarian cancer: platinum combination cytoreduction followed by cyclophosphamide consolidation. 1985, 21 (12):1479-83 Eur J Cancer Clin Oncol
    Journal
    European Journal of Cancer & Clinical Oncology
    URI
    http://hdl.handle.net/10541/116916
    DOI
    10.1016/0277-5379(85)90242-1
    PubMed ID
    2420603
    Type
    Article
    Language
    en
    ISSN
    0277-5379
    ae974a485f413a2113503eed53cd6c53
    10.1016/0277-5379(85)90242-1
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