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dc.contributor.authorHume, W J
dc.contributor.authorSaffhill, Roy
dc.date.accessioned2010-12-01T10:35:26Z
dc.date.available2010-12-01T10:35:26Z
dc.date.issued1986-11
dc.identifier.citationIodo- and bromodeoxyuridine are excised at different rates from DNA of mouse tongue keratinocytes in vitro. 1986, 60 (2):227-32 Chem Biol Interacten
dc.identifier.issn0009-2797
dc.identifier.pmid2431799
dc.identifier.doi10.1016/0009-2797(86)90031-1
dc.identifier.urihttp://hdl.handle.net/10541/116847
dc.description.abstractThe development of antibodies to iododeoxyuridine (IdU) and bromodeoxyuridine (BrdU) has increased interest in the use of these compounds in cell biology. However, little is known about their metabolism in vivo and in vitro. In this paper we show that, contrary to the impression gained from earlier studies, these compounds are not stably incorporated into DNA of mouse tongue epithelial cells in vitro but are removed, with turnover times of 1.0 days (BrdU) and 3.8 days (IdU).
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshBromodeoxyuridine
dc.subject.meshDNA
dc.subject.meshEpidermis
dc.subject.meshIdoxuridine
dc.subject.meshKeratins
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshTongue
dc.titleIodo- and bromodeoxyuridine are excised at different rates from DNA of mouse tongue keratinocytes in vitro.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital, Manchester M20 9BX UK.en
dc.identifier.journalChemico-Biological Interactionsen
html.description.abstractThe development of antibodies to iododeoxyuridine (IdU) and bromodeoxyuridine (BrdU) has increased interest in the use of these compounds in cell biology. However, little is known about their metabolism in vivo and in vitro. In this paper we show that, contrary to the impression gained from earlier studies, these compounds are not stably incorporated into DNA of mouse tongue epithelial cells in vitro but are removed, with turnover times of 1.0 days (BrdU) and 3.8 days (IdU).


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