Iodo- and bromodeoxyuridine are excised at different rates from DNA of mouse tongue keratinocytes in vitro.
Affiliation
Paterson Laboratories, Christie Hospital, Manchester M20 9BX UK.Issue Date
1986-11
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The development of antibodies to iododeoxyuridine (IdU) and bromodeoxyuridine (BrdU) has increased interest in the use of these compounds in cell biology. However, little is known about their metabolism in vivo and in vitro. In this paper we show that, contrary to the impression gained from earlier studies, these compounds are not stably incorporated into DNA of mouse tongue epithelial cells in vitro but are removed, with turnover times of 1.0 days (BrdU) and 3.8 days (IdU).Citation
Iodo- and bromodeoxyuridine are excised at different rates from DNA of mouse tongue keratinocytes in vitro. 1986, 60 (2):227-32 Chem Biol InteractJournal
Chemico-Biological InteractionsDOI
10.1016/0009-2797(86)90031-1PubMed ID
2431799Type
ArticleLanguage
enISSN
0009-2797ae974a485f413a2113503eed53cd6c53
10.1016/0009-2797(86)90031-1
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