Dose and time related responses of the irradiated prepubertal rat testis. I. Leydig cell function.
Affiliation
Department of Radiobiology, Paterson Laboratories, Christie Hospital and Holt Radium InstituteIssue Date
1985-12
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Show full item recordAbstract
The testes of prepubertal rats were locally irradiated with 300 kVp x-rays to doses of between 1 and 15 Gy. Leydig cell function was assessed between 2 and 36 weeks post-irradiation. Dysfunction was observed at two weeks as evidenced by a reduction in serum levels of testosterone to between 40 and 70% of control, with a threshold dose of about 5 Gy. Endocrine deficiencies in the Leydig cell population were indicated at later times by increased serum levels of LH, although serum testosterone concentrations recovered to control levels. The elevations in serum LH increased with time suggesting progressive Leydig cell failure.Citation
Dose and time related responses of the irradiated prepubertal rat testis. I. Leydig cell function. 1985, 8 (6):459-71 In. J AndrolJournal
International Journal of AndrologyDOI
10.1111/j.1365-2605.1985.tb00859.xPubMed ID
3011683Type
ArticleLanguage
enISSN
0105-6263ae974a485f413a2113503eed53cd6c53
10.1111/j.1365-2605.1985.tb00859.x
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