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    The sensitivity of G0-state haemopoietic spleen colony-forming cells to a stimulus for proliferation.

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    Authors
    Lord, Brian I
    Affiliation
    The Paterson Laboratories, Wilmslow Road, Withington, Manchester, M20 9BX, UK.
    Issue Date
    1986-05
    
    Metadata
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    Abstract
    Haemopoietic spleen colony-forming units (CFU-s) close to the axis (axial CFU-s) of the long bones have a high probability of self-renewal. They are pluripotent cells and are largely in a G0-State. By contrast, CFU-s close to the bone surface (marginal CFU-s) have a lower probability of self-renewal and are probably more mature, though still pluripotent. Most CFU-s proliferation arises in this zone. As a consequence, marginal CFU-s tend to have shorter G0 histories than do axial CFU-s. Femoral marrow was, therefore, divided into axial and marginal populations and the sensitivity of the CFU-s to an endogenous CFU-s-specific proliferation-stimulating factor was assessed and compared by the tritiated thymidine suicide technique. It was found that axial CFU-s are considerably more resistant to stimulation than are marginal CFU-s in that larger doses for longer periods of exposure are required to increase the proliferative activity of the cells. This behaviour is consistent with the suggestion that cells with a low division probability exist in deeper levels of the quiescent G0-state. Although this hypothesis was developed from the behaviour of cells maintained in culture under sub-optimal physiological conditions, this phenomenon appears, in vivo, to be a characteristic of the stem cell population of haemopoietic tissue; their high resistance to stimulation maintaining the axial CFU-s in a quiescent state.
    Citation
    The sensitivity of G0-state haemopoietic spleen colony-forming cells to a stimulus for proliferation. 1986, 19 (3):305-10 Cell Tissue Kinet
    Journal
    Cell and Tissue Kinetics
    URI
    http://hdl.handle.net/10541/116792
    DOI
    10.1111/j.1365-2184.1986.tb00682.x
    PubMed ID
    3719662
    Type
    Article
    Language
    en
    ISSN
    0008-8730
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2184.1986.tb00682.x
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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