The radiosensitivity of cultured human and mouse keratinocytes.
| dc.contributor.author | Parkinson, E | |
| dc.contributor.author | Hume, W J | |
| dc.contributor.author | Potten, Christopher S | |
| dc.date.accessioned | 2010-11-30T18:29:08Z | |
| dc.date.available | 2010-11-30T18:29:08Z | |
| dc.date.issued | 1986-10 | |
| dc.identifier.citation | The radiosensitivity of cultured human and mouse keratinocytes. 1986, 50 (4):717-26 Int J Radiat Biol Rela Stud Phys Chem Med | en |
| dc.identifier.issn | 0020-7616 | |
| dc.identifier.pmid | 2428764 | |
| dc.identifier.doi | 10.1080/09553008614551111 | |
| dc.identifier.uri | http://hdl.handle.net/10541/116779 | |
| dc.description.abstract | Clonogenic survival assays after gamma-radiation in vitro were performed on freshly isolated and subcultured keratinocytes from mouse skin, mouse tongue and human skin. Survival curves were constructed by fitting the data to a multi-target model of cell survival. When subcultured, keratinocytes from all sites produced survival curves which showed a reduced shoulder region and an increased D0 when compared with their freshly isolated counterparts. Freshly isolated human skin keratinocytes were more radiosensitive than mouse keratinocytes from either skin or tongue. | |
| dc.language.iso | en | en |
| dc.subject.mesh | Animals | |
| dc.subject.mesh | Epidermis | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Keratins | |
| dc.subject.mesh | Mice | |
| dc.subject.mesh | Radiation Tolerance | |
| dc.subject.mesh | Skin | |
| dc.subject.mesh | Tongue | |
| dc.title | The radiosensitivity of cultured human and mouse keratinocytes. | en |
| dc.type | Article | en |
| dc.contributor.department | Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, M20 9BX, UK. | en |
| dc.identifier.journal | International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine | en |
| html.description.abstract | Clonogenic survival assays after gamma-radiation in vitro were performed on freshly isolated and subcultured keratinocytes from mouse skin, mouse tongue and human skin. Survival curves were constructed by fitting the data to a multi-target model of cell survival. When subcultured, keratinocytes from all sites produced survival curves which showed a reduced shoulder region and an increased D0 when compared with their freshly isolated counterparts. Freshly isolated human skin keratinocytes were more radiosensitive than mouse keratinocytes from either skin or tongue. |