AffiliationPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, M20 9BX, UK.
MetadataShow full item record
AbstractClonogenic survival assays after gamma-radiation in vitro were performed on freshly isolated and subcultured keratinocytes from mouse skin, mouse tongue and human skin. Survival curves were constructed by fitting the data to a multi-target model of cell survival. When subcultured, keratinocytes from all sites produced survival curves which showed a reduced shoulder region and an increased D0 when compared with their freshly isolated counterparts. Freshly isolated human skin keratinocytes were more radiosensitive than mouse keratinocytes from either skin or tongue.
CitationThe radiosensitivity of cultured human and mouse keratinocytes. 1986, 50 (4):717-26 Int J Radiat Biol Rela Stud Phys Chem Med
JournalInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
- Cultured skin keratinocytes from both normal individuals and basal cell naevus syndrome patients are more resistant to gamma-rays and UV light compared with cultured skin fibroblasts.
- Authors: Stacey M, Thacker S, Taylor AM
- Issue date: 1989 Jul
- Radiosensitivity of normal human epidermal cells in culture.
- Authors: Dover R, Potten CS
- Issue date: 1983 Jun
- Expression of hair-related keratins in a soft epithelium: subpopulations of human and mouse dorsal tongue keratinocytes express keratin markers for hair-, skin- and esophageal-types of differentiation.
- Authors: Dhouailly D, Xu C, Manabe M, Schermer A, Sun TT
- Issue date: 1989 Mar
- Sensing radiosensitivity of human epidermal stem cells.
- Authors: Rachidi W, Harfourche G, Lemaitre G, Amiot F, Vaigot P, Martin MT
- Issue date: 2007 Jun
- Fibroblast radiosensitivity in vitro and lung fibrosis in vivo: comparison between a fibrosis-prone and fibrosis-resistant mouse strain.
- Authors: Dileto CL, Travis EL
- Issue date: 1996 Jul