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dc.contributor.authorChang, James
dc.contributor.authorCoutinho, Lucia H
dc.contributor.authorMorgenstern, Godfrey R
dc.contributor.authorScarffe, J Howard
dc.contributor.authorDeakin, David P
dc.contributor.authorHarrison, Christine J
dc.contributor.authorTesta, Nydia G
dc.contributor.authorDexter, T Michael
dc.date.accessioned2010-11-30T16:55:19Z
dc.date.available2010-11-30T16:55:19Z
dc.date.issued1986-02-08
dc.identifier.citationReconstitution of haemopoietic system with autologous marrow taken during relapse of acute myeloblastic leukaemia and grown in long-term culture. 1986, 1 (8476):294-5 Lanceten
dc.identifier.issn0140-6736
dc.identifier.pmid2868165
dc.identifier.doi10.1016/S0140-6736(86)90828-7
dc.identifier.urihttp://hdl.handle.net/10541/116769
dc.description.abstractIn long-term cultures of bone marrow from a patient with acute myeloblastic leukaemia (AML) the leukaemic chromosome marker, which was present in a proportion of the marrow cells even during morphological remission, was not detectable after seven days of culture. After florid relapse of AML, large-scale bone marrow cultures were established while the patient received conditioning with cyclophosphamide and total body irradiation as for an allogeneic bone marrow transplant. Marrow cultured for ten days was reinfused and three and six months later the patient was in clinical remission with a normal karyotype.
dc.language.isoenen
dc.subjectAnticancerous Combined Chemotherapy Protocolsen
dc.subjectHaematopoiesisen
dc.subjectAcute Myeloid Leukaemiaen
dc.subject.meshAdolescent
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols
dc.subject.meshBone Marrow
dc.subject.meshBone Marrow Transplantation
dc.subject.meshCombined Modality Therapy
dc.subject.meshCulture Media
dc.subject.meshCyclophosphamide
dc.subject.meshHematopoiesis
dc.subject.meshHumans
dc.subject.meshKaryotyping
dc.subject.meshLeukemia, Myeloid, Acute
dc.subject.meshMale
dc.subject.meshPremedication
dc.subject.meshRecurrence
dc.subject.meshTime Factors
dc.subject.meshTransplantation, Autologous
dc.subject.meshWhole-Body Irradiation
dc.titleReconstitution of haemopoietic system with autologous marrow taken during relapse of acute myeloblastic leukaemia and grown in long-term culture.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Haematology, Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, M20 4BX, UK.en
dc.identifier.journalLanceten
html.description.abstractIn long-term cultures of bone marrow from a patient with acute myeloblastic leukaemia (AML) the leukaemic chromosome marker, which was present in a proportion of the marrow cells even during morphological remission, was not detectable after seven days of culture. After florid relapse of AML, large-scale bone marrow cultures were established while the patient received conditioning with cyclophosphamide and total body irradiation as for an allogeneic bone marrow transplant. Marrow cultured for ten days was reinfused and three and six months later the patient was in clinical remission with a normal karyotype.


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