Reconstitution of haemopoietic system with autologous marrow taken during relapse of acute myeloblastic leukaemia and grown in long-term culture.
Authors
Chang, JamesCoutinho, Lucia H
Morgenstern, Godfrey R
Scarffe, J Howard
Deakin, David P
Harrison, Christine J
Testa, Nydia G
Dexter, T Michael
Affiliation
Department of Experimental Haematology, Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, M20 4BX, UK.Issue Date
1986-02-08
Metadata
Show full item recordAbstract
In long-term cultures of bone marrow from a patient with acute myeloblastic leukaemia (AML) the leukaemic chromosome marker, which was present in a proportion of the marrow cells even during morphological remission, was not detectable after seven days of culture. After florid relapse of AML, large-scale bone marrow cultures were established while the patient received conditioning with cyclophosphamide and total body irradiation as for an allogeneic bone marrow transplant. Marrow cultured for ten days was reinfused and three and six months later the patient was in clinical remission with a normal karyotype.Citation
Reconstitution of haemopoietic system with autologous marrow taken during relapse of acute myeloblastic leukaemia and grown in long-term culture. 1986, 1 (8476):294-5 LancetJournal
LancetDOI
10.1016/S0140-6736(86)90828-7PubMed ID
2868165Type
ArticleLanguage
enISSN
0140-6736ae974a485f413a2113503eed53cd6c53
10.1016/S0140-6736(86)90828-7
Scopus Count
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