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    Immunohistochemical detection of ras oncogene p21 product in benign and malignant mammary tissue in man.

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    Authors
    Ghosh, Anna K
    Moore, Michael
    Harris, Martin
    Affiliation
    Department of Immunology Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, M20 9BX, UK.
    Issue Date
    1986-04
    
    Metadata
    Show full item record
    Abstract
    The monoclonal antibody RAP-5 generated against a synthetic peptide corresponding to amino acid positions 10-17 of the ras p21 protein was used in an immunohistochemical study of the expression of ras in normal, benign, and malignant breast epithelium in man. The staining intensity and intracellular distribution of RAP-5 was similar in the three epithelial populations and extended to other tissue elements including myoepithelial cells, smooth muscle, myelin, capillary endothelium, and stromal fibroblasts, as well as sebaceous glands and sweat glands overlying the breast. These results suggest that RAP-5 recognises a normal cellular component, the expression of which is not more enhanced in hyperplastic or neoplastic conditions. The detection of mutant forms of p21 exclusively expressed in malignant tumours requires that alternative reagents be developed.
    Citation
    Immunohistochemical detection of ras oncogene p21 product in benign and malignant mammary tissue in man. 1986, 39 (4):428-34 J Clin Pathol
    Journal
    Journal of Clinical Pathology
    URI
    http://hdl.handle.net/10541/116738
    DOI
    10.1136/jcp.39.4.428
    PubMed ID
    3009557
    Type
    Article
    Language
    en
    ISSN
    0021-9746
    ae974a485f413a2113503eed53cd6c53
    10.1136/jcp.39.4.428
    Scopus Count
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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