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Dose and time related responses of the irradiated prepubertal rat testis. II. Seminiferous epithelial function.

dc.contributor.authorDelic, Julian I
dc.contributor.authorHendry, Jolyon H
dc.contributor.authorMorris, Ian D
dc.contributor.authorShalet, Stephen M
dc.date.accessioned2010-11-30T16:47:54Z
dc.date.available2010-11-30T16:47:54Z
dc.date.issued1985-12
dc.identifier.citationDose and time related responses of the irradiated prepubertal rat testis. II. Seminiferous epithelial function. 1985, 8 (6):484-96 Int J Androlen
dc.identifier.issn0105-6263
dc.identifier.pmid3938979
dc.identifier.doi10.1111/j.1365-2605.1985.tb00861.x
dc.identifier.urihttp://hdl.handle.net/10541/116737
dc.description.abstractDose-related effects of radiation upon the seminiferous epithelium were examined in the prepubertal rat. Marked damage to the spermatogenic cell populations was produced by doses of 5 Gy and above. As a result serum levels of FSH were increased, maximum changes being observed at 2 weeks, but levels remaining high even at 36 weeks after irradiation. Serum levels of androgen binding protein (ABP) were inversely related to serum FSH. Above a threshold dose of 5 Gy, serum ABP levels were reduced to between 30-50% of control values, possibly indicating damage to the Sertoli cells. Progression in the degree of testicular failure was indicated at 36 weeks after a dose of 15 Gy by further increases in serum gonadotrophins when compared to earlier times and by the absence of spermatogenesis.
dc.language.isoenen
dc.subject.meshAge Factors
dc.subject.meshAndrogen-Binding Protein
dc.subject.meshAnimals
dc.subject.meshBody Weight
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshEpididymis
dc.subject.meshEpithelial Cells
dc.subject.meshEpithelium
dc.subject.meshFollicle Stimulating Hormone
dc.subject.meshMale
dc.subject.meshOrgan Size
dc.subject.meshRats
dc.subject.meshSeminiferous Tubules
dc.subject.meshTestis
dc.subject.meshX-Rays
dc.titleDose and time related responses of the irradiated prepubertal rat testis. II. Seminiferous epithelial function.en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiobiology, Paterson Laboratories, CHristie Hospital and Holt Radium Instituteen
dc.identifier.journalInternational Journal of Andrologyen
html.description.abstractDose-related effects of radiation upon the seminiferous epithelium were examined in the prepubertal rat. Marked damage to the spermatogenic cell populations was produced by doses of 5 Gy and above. As a result serum levels of FSH were increased, maximum changes being observed at 2 weeks, but levels remaining high even at 36 weeks after irradiation. Serum levels of androgen binding protein (ABP) were inversely related to serum FSH. Above a threshold dose of 5 Gy, serum ABP levels were reduced to between 30-50% of control values, possibly indicating damage to the Sertoli cells. Progression in the degree of testicular failure was indicated at 36 weeks after a dose of 15 Gy by further increases in serum gonadotrophins when compared to earlier times and by the absence of spermatogenesis.


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