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    Dose and time related responses of the irradiated prepubertal rat testis. II. Seminiferous epithelial function.

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    Authors
    Delic, Julian I
    Hendry, Jolyon H
    Morris, Ian D
    Shalet, Stephen M
    Affiliation
    Department of Radiobiology, Paterson Laboratories, CHristie Hospital and Holt Radium Institute
    Issue Date
    1985-12
    
    Metadata
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    Abstract
    Dose-related effects of radiation upon the seminiferous epithelium were examined in the prepubertal rat. Marked damage to the spermatogenic cell populations was produced by doses of 5 Gy and above. As a result serum levels of FSH were increased, maximum changes being observed at 2 weeks, but levels remaining high even at 36 weeks after irradiation. Serum levels of androgen binding protein (ABP) were inversely related to serum FSH. Above a threshold dose of 5 Gy, serum ABP levels were reduced to between 30-50% of control values, possibly indicating damage to the Sertoli cells. Progression in the degree of testicular failure was indicated at 36 weeks after a dose of 15 Gy by further increases in serum gonadotrophins when compared to earlier times and by the absence of spermatogenesis.
    Citation
    Dose and time related responses of the irradiated prepubertal rat testis. II. Seminiferous epithelial function. 1985, 8 (6):484-96 Int J Androl
    Journal
    International Journal of Andrology
    URI
    http://hdl.handle.net/10541/116737
    DOI
    10.1111/j.1365-2605.1985.tb00861.x
    PubMed ID
    3938979
    Type
    Article
    Language
    en
    ISSN
    0105-6263
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2605.1985.tb00861.x
    Scopus Count
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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