Effects of puromycin, cycloheximide and noradrenaline on cell migration within the crypts and on the villi of the small intestine. A model to explain cell movement in both regions.
| dc.contributor.author | Kaur, P | |
| dc.contributor.author | Potten, Christopher S | |
| dc.date.accessioned | 2010-11-23T10:31:29Z | |
| dc.date.available | 2010-11-23T10:31:29Z | |
| dc.date.issued | 1986-11 | |
| dc.identifier.citation | Effects of puromycin, cycloheximide and noradrenaline on cell migration within the crypts and on the villi of the small intestine. A model to explain cell movement in both regions. 1986, 19 (6):611-25 Cell Tissue Kinet | en |
| dc.identifier.issn | 0008-8730 | |
| dc.identifier.pmid | 3802184 | |
| dc.identifier.doi | 10.1111/j.1365-2184.1986.tb00762.x | |
| dc.identifier.uri | http://hdl.handle.net/10541/116073 | |
| dc.description.abstract | The normal process of cell migration, occurring as part of the replacement scheme within the small intestinal epithelium, was investigated extensively. The effects of puromycin, cycloheximide and noradrenaline on the movement of tritiated thymidine [( 3H]TdR) prelabelled crypt or villus cells have been studied. These studies have led to the formulation of a model for the mechanism of cell migration, postulating that the crypts and villi behave as separate units, with regard to cell migration, in addition to their distinct structural and functional properties. It is proposed that crypt cell migration is an active process requiring protein synthesis and protein glycosylation, whilst movement of villus epithelial cells is passive, depending on the continued contraction of smooth muscle cells in the lamina propria. | |
| dc.language.iso | en | en |
| dc.subject.mesh | Animals | |
| dc.subject.mesh | Basement Membrane | |
| dc.subject.mesh | Cell Movement | |
| dc.subject.mesh | Cycloheximide | |
| dc.subject.mesh | Epithelial Cells | |
| dc.subject.mesh | Epithelium | |
| dc.subject.mesh | Intestinal Mucosa | |
| dc.subject.mesh | Intestine, Small | |
| dc.subject.mesh | Male | |
| dc.subject.mesh | Mice | |
| dc.subject.mesh | Norepinephrine | |
| dc.subject.mesh | Puromycin | |
| dc.title | Effects of puromycin, cycloheximide and noradrenaline on cell migration within the crypts and on the villi of the small intestine. A model to explain cell movement in both regions. | en |
| dc.type | Article | en |
| dc.contributor.department | Paterson Laboratories, Christie Hospital & Holt Radium Institute, Manchester, M20 9BX, U.K. | en |
| dc.identifier.journal | Cell and Tissue Kinetics | en |
| html.description.abstract | The normal process of cell migration, occurring as part of the replacement scheme within the small intestinal epithelium, was investigated extensively. The effects of puromycin, cycloheximide and noradrenaline on the movement of tritiated thymidine [( 3H]TdR) prelabelled crypt or villus cells have been studied. These studies have led to the formulation of a model for the mechanism of cell migration, postulating that the crypts and villi behave as separate units, with regard to cell migration, in addition to their distinct structural and functional properties. It is proposed that crypt cell migration is an active process requiring protein synthesis and protein glycosylation, whilst movement of villus epithelial cells is passive, depending on the continued contraction of smooth muscle cells in the lamina propria. |