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dc.contributor.authorKaur, P
dc.contributor.authorPotten, Christopher S
dc.date.accessioned2010-11-23T10:20:33Z
dc.date.available2010-11-23T10:20:33Z
dc.date.issued1986-11
dc.identifier.citationCircadian variation in migration velocity in small intestinal epithelium. 1986, 19 (6):591-9 Cell Tissue Kineten
dc.identifier.issn0008-8730
dc.identifier.pmid3802183
dc.identifier.doi10.1111/j.1365-2184.1986.tb00760.x
dc.identifier.urihttp://hdl.handle.net/10541/116071
dc.description.abstractThe variation in migration rates of cells within the small intestinal epithelium was studied over a 24-hr period at 3-hr intervals (migration of cells was studied independently for the crypts and the villi using the changing distributions of [3H]TdR labelled cells as an indicator of cell migration). Clear changes in the rates of cell movement were observed during a 24-hr period for both crypt and villus epithelium. The rates of cell migration in these two compartments did not correlate well with the exception of samples taken at 18.00 hours. At this time of day there appeared to be no cell movement at all in either crypts or villi. There was not a good correlation between the migration velocity throughout the day and the changes in the number of mitoses. It is proposed that mitotic rates do not directly govern migration rates but that the converse may be true. Further, the lack of correlation between crypt and villus migration rates at any time of day suggest that the mechanisms controlling all movement in these two regions of small intestinal epithelium may be different.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCell Movement
dc.subject.meshCircadian Rhythm
dc.subject.meshEpithelial Cells
dc.subject.meshHumans
dc.subject.meshIntestinal Mucosa
dc.subject.meshIntestine, Small
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshMitosis
dc.titleCircadian variation in migration velocity in small intestinal epithelium.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Withington, Manchester M20 9BX, U.K.en
dc.identifier.journalCell and Tissue Kineticsen
html.description.abstractThe variation in migration rates of cells within the small intestinal epithelium was studied over a 24-hr period at 3-hr intervals (migration of cells was studied independently for the crypts and the villi using the changing distributions of [3H]TdR labelled cells as an indicator of cell migration). Clear changes in the rates of cell movement were observed during a 24-hr period for both crypt and villus epithelium. The rates of cell migration in these two compartments did not correlate well with the exception of samples taken at 18.00 hours. At this time of day there appeared to be no cell movement at all in either crypts or villi. There was not a good correlation between the migration velocity throughout the day and the changes in the number of mitoses. It is proposed that mitotic rates do not directly govern migration rates but that the converse may be true. Further, the lack of correlation between crypt and villus migration rates at any time of day suggest that the mechanisms controlling all movement in these two regions of small intestinal epithelium may be different.


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