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Urothelial proliferation in growing mice.

dc.contributor.authorJost, S
dc.contributor.authorPotten, Christopher S
dc.date.accessioned2010-11-23T10:15:42Z
dc.date.available2010-11-23T10:15:42Z
dc.date.issued1986-03
dc.identifier.citationUrothelial proliferation in growing mice. 1986, 19 (2):155-60 Cell Tissue Kineten
dc.identifier.issn0008-8730
dc.identifier.pmid3698072
dc.identifier.doi10.1111/j.1365-2184.1986.tb00725.x
dc.identifier.urihttp://hdl.handle.net/10541/116068
dc.description.abstractDeveloping murine urothelium undergoes pronounced proliferation until at least 10 days after birth. Thereafter, both mitotic and [3H]TdR-labelling indices fall sharply with age. The ratio of labelling to mitotic indices also alters dramatically during development, which is probably due to both endoreduplication and changes in the relative durations of the DNA synthesis and mitotic phases. This ratio reaches stability at 5 weeks of age. The adult labelling and mitotic indices were 0.11 and 0.019% respectively, indicating a very slow turnover.
dc.language.isoenen
dc.subject.meshAging
dc.subject.meshAnimals
dc.subject.meshAutoradiography
dc.subject.meshCell Division
dc.subject.meshDNA Replication
dc.subject.meshEpithelial Cells
dc.subject.meshKinetics
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshMice, Inbred Strains
dc.subject.meshMitotic Index
dc.subject.meshThymidine
dc.subject.meshTritium
dc.subject.meshUrinary Bladder
dc.titleUrothelial proliferation in growing mice.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital & Holt Radium Institute, Manchester, M20 9BX, U.K.en
dc.identifier.journalCell and Tissue Kineticsen
html.description.abstractDeveloping murine urothelium undergoes pronounced proliferation until at least 10 days after birth. Thereafter, both mitotic and [3H]TdR-labelling indices fall sharply with age. The ratio of labelling to mitotic indices also alters dramatically during development, which is probably due to both endoreduplication and changes in the relative durations of the DNA synthesis and mitotic phases. This ratio reaches stability at 5 weeks of age. The adult labelling and mitotic indices were 0.11 and 0.019% respectively, indicating a very slow turnover.


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