• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Cell cycles in cell hierarchies.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Potten, Christopher S
    Affiliation
    Paterson Laboratories, Christie Hospital & Holt Radium Institute, Manchester, M20 9BX, U.K.
    Issue Date
    1986-02
    
    Metadata
    Show full item record
    Abstract
    In the replacing tissues of the body, namely the bone marrow, testis, and the surface epithelia with their appendages, cell replacement would appear to be achieved using an hierarchically organized proliferative compartment with relatively few ultimate stem cells producing dividing transit cells which eventually differentiate and mature into the functional cells of the tissue. The cell cycle times of the various constituents of the hierarchy differ, and the stem cells apparently have a longer cell cycle than the transit cells. There may be variations in the cell cycle as cells pass through the transit population in some cases, e.g. in the bone marrow, while in others the cycle time remains fairly constant, e.g. in the testis. The difference in the cell cycle time between stem cells and transit cells is not completely unequivocal, and there is little or no difference in cycle time in the epithelium on the dorsal surface of the tongue while in other cases the experimental evidence for long stem-cell cycles is somewhat imprecise. However, the epithelium in the small intestine and the spermatogonia in the testis have been fairly extensively studied and here the evidence clearly shows a lengthening of the cell cycle as more primitive cells are considered.
    Citation
    Cell cycles in cell hierarchies. 1986, 49 (2):257-78 Int J Radiat Biol Relat Stud Phys Chem Med
    Journal
    International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
    URI
    http://hdl.handle.net/10541/116050
    DOI
    10.1080/09553008514552541
    PubMed ID
    3510994
    Type
    Article
    Language
    en
    ISSN
    0020-7616
    ae974a485f413a2113503eed53cd6c53
    10.1080/09553008514552541
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • A comparison of cell replacement in bone marrow, testis and three regions of surface epithelium.
    • Authors: Potten CS, Schofield R, Lajtha LG
    • Issue date: 1979 Aug 10
    • Circadian rhythms of presumptive stem cells in three different epithelia of the mouse.
    • Authors: Potten CS, Al-Barwari SE, Hume WJ, Searle J
    • Issue date: 1977 Nov
    • Mathematical models of hierarchically structured cell populations under equilibrium with application to the epidermis.
    • Authors: Savill NJ
    • Issue date: 2003 Feb
    • Regeneration in epithelial proliferative units as exemplified by small intestinal crypts.
    • Authors: Potten CS
    • Issue date: 1991
    • The stem cell continuum: cell cycle, injury, and phenotype lability.
    • Authors: Quesenberry PJ, Colvin G, Dooner G, Dooner M, Aliotta JM, Johnson K
    • Issue date: 2007 Jun
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.