Authors
Lord, Brian IAffiliation
Paterson Laboratories, Christie Hospital & Holt Radium Institute, Manchester, M20 9BX, U.K.Issue Date
1986-02
Metadata
Show full item recordAbstract
The control of cell proliferation, in physiological terms, depends not so much on our understanding of the sequence of biochemical events unfolding as a cell progresses through its proliferation cycle, as upon the recognition by a tissue of the demands for functional cells of a particular type. After considering the modes of control possible, i.e. by recruitment of resting G0-state cells into cycle or by modifying the proliferative behaviour of already proliferating cells, haemopoietic tissue is used as a model to illustrate how the principles of proliferation control in specific cell lineages can be effected. Although the mode of stem cell control is different from that in the maturing populations, all depend on a co-ordination of negative feedback loops for inhibitor and stimulator which are specific to that cell population. The concept of a 'quantal' cell cycle is considered but its application to control in an adult steady-state tissue must be modified to take account of microenvironmental influences which are shown, by their cellular organization, to be an important feature in haemopoietic and probably all other tissues.Citation
Controls on the cell cycle. 1986, 49 (2):279-96 Int J Radiat Biol Relat Stud Phys Chem MedJournal
International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and MedicineDOI
10.1080/09553008514552551PubMed ID
3080380Type
ArticleLanguage
enISSN
0020-7616ae974a485f413a2113503eed53cd6c53
10.1080/09553008514552551