On the nature of the active component of haematoporphyrin 'derivative'.
Affiliation
Paterson Laboratories, Christie Hospital, Manchester M20 9BX UKIssue Date
1986-08
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The active component of the photochemotherapeutic drug 'haematoporphyrin derivative' was studied by laser flash photolysis. The triplet extinction coefficient of this species was determined using a method in which the calculated value is dependent on the assumed molecular weight. This value was then incorporated in the evaluation of the quantum yield of triplet by a comparative technique. Since the maximum possible value of this yield is unity, it is shown that the molecular weight of the active component is greater than or equal to 3000, so that, on average, the drug molecule must contain at least 5 porphyrin units.Citation
On the nature of the active component of haematoporphyrin 'derivative'. 1986, 32 (2):181-5 Cancer LettJournal
Cancer LettersDOI
10.1016/0304-3835(86)90117-5PubMed ID
3756843Type
ArticleLanguage
enISSN
0304-3835EISSN
1872-7980ae974a485f413a2113503eed53cd6c53
10.1016/0304-3835(86)90117-5
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