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    On the nature of the active component of haematoporphyrin 'derivative'.

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    Authors
    Land, Edward J
    Redmond, R
    Truscott, T G
    Affiliation
    Paterson Laboratories, Christie Hospital, Manchester M20 9BX UK
    Issue Date
    1986-08
    
    Metadata
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    Abstract
    The active component of the photochemotherapeutic drug 'haematoporphyrin derivative' was studied by laser flash photolysis. The triplet extinction coefficient of this species was determined using a method in which the calculated value is dependent on the assumed molecular weight. This value was then incorporated in the evaluation of the quantum yield of triplet by a comparative technique. Since the maximum possible value of this yield is unity, it is shown that the molecular weight of the active component is greater than or equal to 3000, so that, on average, the drug molecule must contain at least 5 porphyrin units.
    Citation
    On the nature of the active component of haematoporphyrin 'derivative'. 1986, 32 (2):181-5 Cancer Lett
    Journal
    Cancer Letters
    URI
    http://hdl.handle.net/10541/116017
    DOI
    10.1016/0304-3835(86)90117-5
    PubMed ID
    3756843
    Type
    Article
    Language
    en
    ISSN
    0304-3835
    EISSN
    1872-7980
    ae974a485f413a2113503eed53cd6c53
    10.1016/0304-3835(86)90117-5
    Scopus Count
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    All Paterson Institute for Cancer Research

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