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dc.contributor.authorCoutinho, Lucia H
dc.contributor.authorTesta, Nydia G
dc.contributor.authorDexter, T Michael
dc.date.accessioned2010-11-22T17:35:49Z
dc.date.available2010-11-22T17:35:49Z
dc.date.issued1986-07
dc.identifier.citationThe myelosuppressive effect of recombinant interferon gamma in short-term and long-term marrow cultures. 1986, 63 (3):517-24 Br J Haematolen
dc.identifier.issn0007-1048
dc.identifier.pmid3089271
dc.identifier.doi10.1111/j.1365-2141.1986.tb07529.x
dc.identifier.urihttp://hdl.handle.net/10541/116016
dc.description.abstractThe effect of a highly purified human gamma IFN (r-gamma-IFN) on the growth of haemopoietic progenitors was examined in soft agar assays and in long-term bone marrow cultures. r-gamma-IFN reduced colony formation by progenitor cells of the granulocyte/macrophage lineage (GM-CFC), the erythroid lineage (BFU-E) and multipotent cells (GEMM-CFC), and suppressed haemopoiesis in long-term culture in a dose-related fashion. At high doses (1000 units/ml) r-gamma-IFN appeared to be toxic to the stromal cells of the bone marrow.
dc.language.isoenen
dc.subjectHaematopoietic Stem Cellsen
dc.subject.meshBone Marrow
dc.subject.meshCell Division
dc.subject.meshCells, Cultured
dc.subject.meshColony-Forming Units Assay
dc.subject.meshDepression, Chemical
dc.subject.meshHematopoietic Stem Cells
dc.subject.meshHumans
dc.subject.meshInterferon-gamma
dc.subject.meshRecombinant Proteins
dc.subject.meshTime Factors
dc.titleThe myelosuppressive effect of recombinant interferon gamma in short-term and long-term marrow cultures.en
dc.typeArticleen
dc.identifier.eissn1365-2141
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Wilmslow Road, Withington, Manchester M20 9BX, UKen
dc.identifier.journalBritish Journal of Haematologyen
html.description.abstractThe effect of a highly purified human gamma IFN (r-gamma-IFN) on the growth of haemopoietic progenitors was examined in soft agar assays and in long-term bone marrow cultures. r-gamma-IFN reduced colony formation by progenitor cells of the granulocyte/macrophage lineage (GM-CFC), the erythroid lineage (BFU-E) and multipotent cells (GEMM-CFC), and suppressed haemopoiesis in long-term culture in a dose-related fashion. At high doses (1000 units/ml) r-gamma-IFN appeared to be toxic to the stromal cells of the bone marrow.


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