The myelosuppressive effect of recombinant interferon gamma in short-term and long-term marrow cultures.
Affiliation
Paterson Laboratories, Christie Hospital and Holt Radium Institute, Wilmslow Road, Withington, Manchester M20 9BX, UKIssue Date
1986-07
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The effect of a highly purified human gamma IFN (r-gamma-IFN) on the growth of haemopoietic progenitors was examined in soft agar assays and in long-term bone marrow cultures. r-gamma-IFN reduced colony formation by progenitor cells of the granulocyte/macrophage lineage (GM-CFC), the erythroid lineage (BFU-E) and multipotent cells (GEMM-CFC), and suppressed haemopoiesis in long-term culture in a dose-related fashion. At high doses (1000 units/ml) r-gamma-IFN appeared to be toxic to the stromal cells of the bone marrow.Citation
The myelosuppressive effect of recombinant interferon gamma in short-term and long-term marrow cultures. 1986, 63 (3):517-24 Br J HaematolJournal
British Journal of HaematologyDOI
10.1111/j.1365-2141.1986.tb07529.xPubMed ID
3089271Type
ArticleLanguage
enISSN
0007-1048EISSN
1365-2141ae974a485f413a2113503eed53cd6c53
10.1111/j.1365-2141.1986.tb07529.x
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