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    The myelosuppressive effect of recombinant interferon gamma in short-term and long-term marrow cultures.

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    Authors
    Coutinho, Lucia H
    Testa, Nydia G
    Dexter, T Michael
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Wilmslow Road, Withington, Manchester M20 9BX, UK
    Issue Date
    1986-07
    
    Metadata
    Show full item record
    Abstract
    The effect of a highly purified human gamma IFN (r-gamma-IFN) on the growth of haemopoietic progenitors was examined in soft agar assays and in long-term bone marrow cultures. r-gamma-IFN reduced colony formation by progenitor cells of the granulocyte/macrophage lineage (GM-CFC), the erythroid lineage (BFU-E) and multipotent cells (GEMM-CFC), and suppressed haemopoiesis in long-term culture in a dose-related fashion. At high doses (1000 units/ml) r-gamma-IFN appeared to be toxic to the stromal cells of the bone marrow.
    Citation
    The myelosuppressive effect of recombinant interferon gamma in short-term and long-term marrow cultures. 1986, 63 (3):517-24 Br J Haematol
    Journal
    British Journal of Haematology
    URI
    http://hdl.handle.net/10541/116016
    DOI
    10.1111/j.1365-2141.1986.tb07529.x
    PubMed ID
    3089271
    Type
    Article
    Language
    en
    ISSN
    0007-1048
    EISSN
    1365-2141
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2141.1986.tb07529.x
    Scopus Count
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    All Paterson Institute for Cancer Research

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