Cowan, Richard A
Nuttall, Pamela M
Deakin, David P
AffiliationRegional Department of Medical Physics and Bioengineering, Christie Hospital and Holt Radium Institute, Manchester, UK.
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AbstractIt has shown that, after intravenous administration of autologous lymphocytes labelled with the beta-emitting radionuclide 114Inm, the cells initially migrate normally before succumbing to the toxic effects of the radiation. The radioactive material is then released from the cell and taken up by neighbouring radioresistant macrophages, thereby localizing a field of radiation to the site of lymphocyte death. Using this technique, lymphocytopoenia has been produced in rats. We have measured the whole-body distribution and excretion of radioactivity in patients who received escalating activities of 114Inm-labelled lymphocytes. All patients had active non-Hodgkin's lymphoma involving the spleen and liver which proved resistant to combination chemotherapy and conventional radiotherapy. Following intravenous administration, the labelled cells cleared rapidly from the vasculature with only 15% remaining in the peripheral blood at 30 min. The radioactivity continued to fall over the next 5 days to approximately 3% and was maintained at approximately 2% for up to 90 days. There was an almost immediate uptake of radioactivity by the spleen and liver which reached approximately 85% of the injected dose by 48 h. The localization of radioactivity stabilized by 48 h and thereafter the whole-body content fell by approximately 0.8% per day. Up to 5% of the administered radioactivity accumulated in the bone marrow. The activities administered were too low to produce a therapeutic response and no toxicity was experienced by the patients. A therapeutic study at higher activities is now underway.
Citation114Inm oxine-labelled lymphocytes--therapeutic applications. 1988, 9 (10):797-802 Nucl Med Commun
JournalNuclear Medicine Communications
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- Authors: Hamilton D, Cowan RA, Sharma HL, Drayson M, Nuttall PM, Wagstaff J, Deakin DP, Crowther D
- Issue date: 1988 Apr
- Tumour imaging of indium-111 oxine-labelled autologous lymphocytes as a staging method in Hodgkin's disease.
- Authors: Grimfors G, Schnell PO, Holm G, Johansson B, Mellstedt H, Pihlstedt P, Björkholm M
- Issue date: 1989 Mar
- Dynamic studies of lymphocytes labelled with indium-111 during and after treatment with monoclonal anti-idiotype antibody in advanced B cell lymphoma.
- Authors: Rankin EM, Hekman A, Hardeman MR, Hoefnagel CA
- Issue date: 1984 Oct 27
- Increased blood clearance rate of indium-111 oxine-labeled autologous CD4+ blood cells in untreated patients with Hodgkin's disease.
- Authors: Grimfors G, Holm G, Mellstedt H, Schnell PO, Tullgren O, Björkholm M
- Issue date: 1990 Aug 1
- Treatment of lymphoid cell malignancy with In-114m labelled autologous lymphocytes.
- Authors: Sharma HL, Cowan RA, Murby B, Owens S, Nuttall PM, Gunton D, Smith AM, Chang J, Crowther D
- Issue date: 1997 May-Jun