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    The definition of the 'no change' category in patients treated with endocrine therapy and chemotherapy for advanced carcinoma of the breast.

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    Authors
    Howell, Anthony
    Mackintosh, J
    Jones, Mary
    Redford, J
    Wagstaff, John
    Sellwood, R A
    Affiliation
    CRC Department of Medical Oncology, Christie Hospital, Manchester, U.K.
    Issue Date
    1988-10
    
    Metadata
    Show full item record
    Abstract
    In the criteria used for assessment of response to treatment for advanced breast cancer the definition of no change (NC) is clear; however, there is no indication of the duration of stabilization required for patients to qualify for this category of response. We have made the assumption that NC is a worthwhile category of response if the overall time to progression (TTP) and survival of this group is not significantly different from patients with partial remissions (PR). Two hundred and sixty-three evaluable patients treated with endocrine therapy and 302 evaluable chemotherapy-treated patients were studied and the TTP and survival curves for PR and periods of NC from 1 to 6 months compared. For the endocrine-treated patients the TTP and survival curves for NC became non-significantly different from the PR curves after 4 and 5 months respectively. For chemotherapy-treated patients the TTP curves became non-significantly different from PR at 4 months and for survival the period was 3 months. In order to define NC as a useful category of response and to eliminate the possibility that NC taken for a shorter period could simply represent a slowly progressive tumour, we suggest that the minimum period of disease stabilization be taken as 5 months for both endocrine- and chemotherapy-treated patients.
    Citation
    The definition of the 'no change' category in patients treated with endocrine therapy and chemotherapy for advanced carcinoma of the breast. 1988, 24 (10):1567-72 Eur J Cancer Clin Oncol
    Journal
    European Journal of Cancer & Clinical Oncology
    URI
    http://hdl.handle.net/10541/116013
    DOI
    10.1016/0277-5379(88)90046-6
    PubMed ID
    3208800
    Type
    Article
    Language
    en
    ISSN
    0277-5379
    ae974a485f413a2113503eed53cd6c53
    10.1016/0277-5379(88)90046-6
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