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    Prognostic factors in stage I and II high and intermediate grade non-Hodgkin's lymphoma.

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    Authors
    Mackintosh, J F
    Cowan, Richard A
    Jones, Mary
    Harris, Martin
    Deakin, David P
    Crowther, Derek
    Affiliation
    CRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Manchester, U.K.
    Issue Date
    1988-10
    
    Metadata
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    Abstract
    Between 1975 and 1986, the Manchester Lymphoma Group treated 127 patients with localized (Stages I/II) high and intermediate grade non-Hodgkin's lymphoma (NHL) on one of three protocols of combined involved field radiotherapy and chemotherapy. The study included patients with widespread bulky abdominal disease providing there was no apparent spread outside the abdomen and the liver was not involved with metastatic disease. The median duration of follow-up was 70 months. The complete response rate was 86% and the overall 5-year survival was 70%. The 5-year relapse-free survival of the complete responders was 80%. Cox model multivariate analysis showed that bulk disease (greater than 5 cm), low serum albumin and gut involvement were the pretreatment factors associated with shorter survival. When remission status was included in the model the attainment of a complete response was the major determinant of long-term survival but bulk disease and gut involvement were still significant adverse predictors for survival. These factors need to be assessed when analysing results of therapy in NHL and in the design of future treatment strategies.
    Citation
    Prognostic factors in stage I and II high and intermediate grade non-Hodgkin's lymphoma. 1988, 24 (10):1617-22 Eur J Cancer Clin Oncol
    Journal
    European Journal of Cancer & Clinical Oncology
    URI
    http://hdl.handle.net/10541/116012
    DOI
    10.1016/0277-5379(88)90054-5
    PubMed ID
    3208806
    Type
    Article
    Language
    en
    ISSN
    0277-5379
    ae974a485f413a2113503eed53cd6c53
    10.1016/0277-5379(88)90054-5
    Scopus Count
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