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dc.contributor.authorSarawar, S
dc.contributor.authorSchlingemann, R
dc.contributor.authorKelsey, Anna M
dc.contributor.authorFleming, S
dc.contributor.authorKumar, Shant
dc.date.accessioned2010-11-22T17:02:05Z
dc.date.available2010-11-22T17:02:05Z
dc.date.issued1988-12
dc.identifier.citationA monoclonal antibody stains blastemal but not tubular components of Wilms' tumour. 1988, 156 (4):319-24 J Patholen
dc.identifier.issn0022-3417
dc.identifier.pmid2852240
dc.identifier.doi10.1002/path.1711560408
dc.identifier.urihttp://hdl.handle.net/10541/116010
dc.description.abstractThe monoclonal antibody PAL-E is specific for endothelial cells in a wide variety of normal and tumour tissue. In normal kidney, PAL-E reacts exclusively with the endothelium of non-glomerular blood vessels. In Wilms' tumour, binding of PAL-E was not restricted to the endothelium; staining of blastemal cells was observed in seven out of eight cases examined. Mesenchymal and tubular components, if present in Wilms' tumour, were negative. In contrast, a monoclonal antibody to Factor VIII-related antigen (RFF-8-R-1) bound only to endothelial cells in these tumours. In fetal kidney, PAL-E binding showed a wider distribution than in adult kidney and both stromal and glomerular capillaries were stained. Tubules and non-endothelial stromal cells were negative. These results indicate that the reactivity of the monoclonal antibody, PAL-E, is not restricted to cells of endothelial origin in all tissues. The implications of these findings for the differentiation of Wilms' tumour are discussed.
dc.language.isoenen
dc.subjectFoetusen
dc.subjectKidney Canceren
dc.subjectWilms Tumouren
dc.subject.meshAdult
dc.subject.meshAntibodies, Monoclonal
dc.subject.meshAntigens
dc.subject.meshEndothelium, Vascular
dc.subject.meshFactor VIII
dc.subject.meshFetus
dc.subject.meshHumans
dc.subject.meshKidney
dc.subject.meshKidney Glomerulus
dc.subject.meshKidney Neoplasms
dc.subject.meshKidney Tubules
dc.subject.meshWilms Tumor
dc.subject.meshvon Willebrand Factor
dc.titleA monoclonal antibody stains blastemal but not tubular components of Wilms' tumour.en
dc.typeArticleen
dc.contributor.departmentClinical Research Laboratories, Christie Hospital, Manchester, U.K.en
dc.identifier.journalJournal of Pathologyen
html.description.abstractThe monoclonal antibody PAL-E is specific for endothelial cells in a wide variety of normal and tumour tissue. In normal kidney, PAL-E reacts exclusively with the endothelium of non-glomerular blood vessels. In Wilms' tumour, binding of PAL-E was not restricted to the endothelium; staining of blastemal cells was observed in seven out of eight cases examined. Mesenchymal and tubular components, if present in Wilms' tumour, were negative. In contrast, a monoclonal antibody to Factor VIII-related antigen (RFF-8-R-1) bound only to endothelial cells in these tumours. In fetal kidney, PAL-E binding showed a wider distribution than in adult kidney and both stromal and glomerular capillaries were stained. Tubules and non-endothelial stromal cells were negative. These results indicate that the reactivity of the monoclonal antibody, PAL-E, is not restricted to cells of endothelial origin in all tissues. The implications of these findings for the differentiation of Wilms' tumour are discussed.


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