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    Growth response to growth hormone therapy following cranial irradiation.

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    Authors
    Clayton, P
    Shalet, Stephen M
    Price, D
    Affiliation
    Department of Child Health, Royal Manchester Children's Hospital, Pendelbury, UK.
    Issue Date
    1988-08
    
    Metadata
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    Abstract
    The growth response to growth hormone (GH) therapy has been studied in 12 children who received irradiation to the cranium alone either for brain gliomas, distant from the hypothalamic-pituitary axis, or as prophylaxis against CNS leukaemia. Seven children have completed GH treatment (mean duration 4 years) and five are presently on GH (mean duration 1.2 years). This response has been compared to that seen in 14 children with isolated idiopathic GH deficiency (IGHD), following GH therapy. Before treatment, the cranially irradiated patients (C-PRGHD) had higher standard deviation scores (SDS) for standing height, sitting height and leg length, and less bone age (BA) retardation, but started treatment at a similar age, and with a similar pre-treatment growth velocity and GH peak to standard provocative tests, compared to IGHD patients. GH produced a significant and similar increase in growth velocity (cm/year and SDS for BA) over the first 2 years' treatment in both groups. However C-PRGHD patients entered puberty and thus completed growth earlier than the IGHD group. As a result, cranially-irradiated children showed no change in height SDS with GH therapy, compared to catch-up growth in IGHD. Nevertheless, GH has enabled C-PRGHD patients to maintain their centile position and to achieve a more acceptable final height.
    Citation
    Growth response to growth hormone therapy following cranial irradiation. 1988, 147 (6):593-6 Eur J Pediatr
    Journal
    European Journal of Pediatrics
    URI
    http://hdl.handle.net/10541/115985
    DOI
    10.1007/BF00442470
    PubMed ID
    3181199
    Type
    Article
    Language
    en
    ISSN
    0340-6199
    ae974a485f413a2113503eed53cd6c53
    10.1007/BF00442470
    Scopus Count
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