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    In situ hybridisation and S1 mapping show that the presence of infiltrating plasma cells is associated with poor prognosis in breast cancer.

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    Authors
    Parkes, H
    Collis, P
    Baildam, Andrew D
    Ralphs, D
    Lyons, B
    Howell, Anthony
    Craig, R
    Affiliation
    Cancer Research Campaign Tumour Endocrinology Group, Medical Molecular Biology Unit, University College and Middlesex School of Medicine, London, UK.
    Issue Date
    1988-12
    
    Metadata
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    Abstract
    In order to identify potential markers of prognosis in breast cancer, representative cDNA libraries were constructed using RNA isolated from primary breast tumour tissue associated with good and poor prognosis. Cross-screening of these libraries repeatedly identified cloned mRNA species associated with the immune system, in particular B-cells, in libraries derived from tumours of poor prognosis. We have used one of these a kappa IV light chain cDNA probe, in two complementary studies to investigate the relationship between immunoglobin gene expression and prognosis. The results obtained using a combination of S1 mapping, RNA blotting and in situ hybridisation demonstrate that the presence of plasma cells, as defined by infiltrating cells which express high levels of immunoglobulin kappa-chain mRNA, is associated with a poor prognosis.
    Citation
    In situ hybridisation and S1 mapping show that the presence of infiltrating plasma cells is associated with poor prognosis in breast cancer. 1988, 58 (6):715-22 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/115974
    PubMed ID
    3224077
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Christie Publications

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