Gastrointestinal stromal tumor with structures resembling intracytoplasmic lumina.
AffiliationDepartment of Pathology, Fudan University Cancer Center, Shanghai, China. Lilysh21@hotmail.com
MetadataShow full item record
AbstractGastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gut. It is characterized by positive immunostaining for CD117, and bears mutations in the c-kit or PDGFRA genes. Its origin remains uncertain. GISTs mainly possess primitive smooth muscle or neuronal differentiation. Although an epithelioid pattern of GIST is a common finding on light microscopy, true epithelial differentiation has never been demonstrated by either immunohistochemistry or ultrastructural study. Here the authors report an epithelioid GIST of the stomach, immunopositive for CD117, DOG1.1, CD34, and PDGFRA, with slight cytoplasmic staining for epithelial membrane antigen. One heterozygous mutation on codon 842 of exon 18 of the PDGFRA gene was also found. Ultrastructurally, tumor cells had plentiful organelles, including some membrane-bound, dense-core granules and cytoplasmic vacuoles. Intermingled thin cellular processes were also found. Unusually, there were many structures resembling glandular epithelial intracellular lumina with processes. The processes, although resembling microvilli, did not have filament cores, while the lumina were either empty or contained some dense or flocculent content of uncertain nature. True intracellular lumina are very rare in GIST and the authors present findings related to this issue, with a discussion on their nature, origin, and significance.
CitationGastrointestinal stromal tumor with structures resembling intracytoplasmic lumina. 2010, 34 (5):301-6 Ultrastruct Pathol
- Gastrointestinal stromal tumor: an ultrastructural investigation on regional differences with considerations on their histogenesis.
- Authors: Min KW
- Issue date: 2010 May
- Monoclonal antibody DOG1.1 shows higher sensitivity than KIT in the diagnosis of gastrointestinal stromal tumors, including unusual subtypes.
- Authors: Liegl B, Hornick JL, Corless CL, Fletcher CD
- Issue date: 2009 Mar
- Comparative ultrastructural analysis and KIT/PDGFRA genotype in 125 gastrointestinal stromal tumors.
- Authors: Agaram NP, Baren A, Arkun K, Dematteo RP, Besmer P, Antonescu CR
- Issue date: 2006 Nov-Dec
- Gastrointestinal stromal tumors presenting as omental masses--a clinicopathologic analysis of 95 cases.
- Authors: Miettinen M, Sobin LH, Lasota J
- Issue date: 2009 Sep
- [c-Kit and PDGFRA mutations and clinico-morphological features of gastrointestinal stromal tumors].
- Authors: Beliakov IS, Anurova OA, Snigur PV, Tsyganova IV, Sel'chuk VIu, Mazurenko NN
- Issue date: 2007