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    Rechallenging with anthracyclines and taxanes in metastatic breast cancer.

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    Authors
    Palmieri, C
    Krell, J
    James, C R
    Harper-Wynne, C
    Misra, Vivek
    Cleator, S
    Miles, D
    Affiliation
    Cancer Research UK Laboratories, Department of Oncology, MRC Cyclotron Building, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 ONN, UK. c.palmieri@imperial.ac.uk
    Issue Date
    2010-10
    
    Metadata
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    Abstract
    Adjuvant use of anthracycline-taxane combination therapy is an accepted strategy in the management of high-risk early-stage breast cancer. However, the introduction of this regimen raises the question of how best to manage those patients who relapse following adjuvant therapy, and whether there is a role for rechallenging in the metastatic setting with the same agent, or class of agent, that has been utilized in the adjuvant setting. This Review examines the evidence for rechallenging with both anthracyclines and taxanes, and highlights the issues that need to be examined in the context of future clinical trials.
    Citation
    Rechallenging with anthracyclines and taxanes in metastatic breast cancer. 2010, 7 (10):561-74 Nat Rev Clin Oncol
    Journal
    Nature Reviews: Clinical Oncology
    URI
    http://hdl.handle.net/10541/115825
    DOI
    10.1038/nrclinonc.2010.122
    PubMed ID
    20808300
    Type
    Article
    Language
    en
    ISSN
    1759-4782
    ae974a485f413a2113503eed53cd6c53
    10.1038/nrclinonc.2010.122
    Scopus Count
    Collections
    All Christie Publications
    Clinical Oncology

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