• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    A retrospective analysis of selective internal radiation therapy (SIRT) with yttrium-90 microspheres in patients with unresectable hepatic malignancies.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Omed, A
    Lawrance, Jeremy A L
    Murphy, G
    Laasch, Hans-Ulrich
    Wilson, G
    Illidge, Timothy M
    Tipping, Jill
    Zivanovic, M
    Jeans, S
    Affiliation
    Manchester Medical School, University of Manchester, Stopford Building, Manchester, UK. aliomed0101@doctors.org.uk
    Issue Date
    2010-09
    
    Metadata
    Show full item record
    Abstract
    AIM: To evaluate the efficacy and safety of selective internal radiation therapy (SIRT). MATERIALS AND METHODS: A retrospective analysis was undertaken of all patients who underwent SIRT at a single institution. Diagnostic and therapeutic angiograms, computed tomography (CT) images, positron-emission tomography (PET) images, and planar isotope images were analysed. The response to SIRT was analysed using radiological data and tumour markers. Overall survival, complications, and side effects of SIRT were also analysed. RESULTS: The initial 12 patients were included on an intention-to-treat basis, between 21/09/2005 and 07/05/2008. All patients had advanced disease and multiple prior courses of chemotherapy. One patient did not receive yttrium-90 due to complex vascular anatomy; the remaining 11 patients underwent 13 SIRT treatment episodes following work-up angiography. A response was seen using PET in 80% of patients. Using CT, the response of the tumour to therapy in the treated hepatic segments demonstrated a 20% partial response, stable disease in 50%, and progressive disease in 30%. Estimated median survival was 229 days, with 64% of patients still alive at the time of writing. No major complications were observed, although 82% of patients experienced side-effects following SIRT, mainly nausea, vomiting, and abdominal pain. CONCLUSIONS: There have been no complications in the 12 SIRT patients. Tumour response was seen in four out of five patients who underwent PET. Objective CT response rates were mixed and are perhaps partially explained by advanced disease and limitations of using measurements to assess response. This complex and potentially hazardous service has been successfully and safely established.
    Citation
    A retrospective analysis of selective internal radiation therapy (SIRT) with yttrium-90 microspheres in patients with unresectable hepatic malignancies. 2010, 65 (9):720-8 Clin Radiol
    Journal
    Clinical Radiology
    URI
    http://hdl.handle.net/10541/115816
    DOI
    10.1016/j.crad.2010.05.001
    PubMed ID
    20696299
    Type
    Article
    Language
    en
    ISSN
    1365-229X
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.crad.2010.05.001
    Scopus Count
    Collections
    All Christie Publications
    Radiology
    Clinical Oncology

    entitlement

    Related articles

    • Selective internal radiation therapy with SIR-Spheres in patients with nonresectable liver tumors.
    • Authors: Pöpperl G, Helmberger T, Münzing W, Schmid R, Jacobs TF, Tatsch K
    • Issue date: 2005 Apr
    • Selective intraarterial radionuclide therapy with Yttrium-90 (Y-90) microspheres for unresectable primary and metastatic liver tumors.
    • Authors: Kucuk ON, Soydal C, Lacin S, Ozkan E, Bilgic S
    • Issue date: 2011 Aug 6
    • Radiation microsphere-induced GI ulcers after selective internal radiation therapy for hepatic tumors: an underrecognized clinical entity.
    • Authors: Konda A, Savin MA, Cappell MS, Duffy MC
    • Issue date: 2009 Sep
    • Initial outcome after selective intraarterial radionuclide therapy with yttrium-90 microspheres as salvage therapy for unresectable metastatic liver disease.
    • Authors: Turkmen C, Ucar A, Poyanli A, Vatankulu B, Ozkan G, Basaran M, Serin K, Sanli Y, Adalet I
    • Issue date: 2013 Sep
    • Selective internal radiation therapy with 90Y microspheres for colorectal liver metastases: single-centre experience with 100 patients.
    • Authors: Stubbs RS, O'Brien I, Correia MM
    • Issue date: 2006 Aug
    DSpace software (copyright © 2002 - 2019)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.