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dc.contributor.authorMukherjee, Annice
dc.contributor.authorHelbert, M
dc.contributor.authorDavis, J R E
dc.contributor.authorShalet, Stephen M
dc.date.accessioned2010-11-18T11:31:37Z
dc.date.available2010-11-18T11:31:37Z
dc.date.issued2009-12-18
dc.identifier.citationImmune function in hypopituitarism; time to reconsider? 2009: Clin Endocrinolen
dc.identifier.issn1365-2265
dc.identifier.pmid20039902
dc.identifier.doi10.1111/j.1365-2265.2009.03751.x
dc.identifier.urihttp://hdl.handle.net/10541/115787
dc.description.abstractAbstract Hypopituitarism is not currently considered as a potential cause of immune disruption in humans. Accumulating data from in-vitro and animal models support a role for the pituitary gland in immune regulation. Furthermore the increased mortality risk noted in patients with adult hypopituitarism remains poorly explained and immune dysfunction could conceivably contribute to this observation. In a recent issue of Clinical & Experimental Immunology we presented new data relating to immune status in adults with treated, severe hypopituitarism. We observed humoral immune deficiency in a significant proportion, despite stable pituitary replacement, including growth hormone (GH). This was especially evident in those with low pre-treatment IGF-I levels and appeared independent of anticonvulsant use or corticosteroid replacement. These observations require substantiation with future studies. In this short review we summarise existing data relating to the effects of pituitary hormones on immune function, and discuss potential clinical implications surrounding the hypothesis of immune dysregulation in severe hypopituitarism.
dc.languageENG
dc.language.isoenen
dc.subjectHypopituitarismen
dc.subjectImmune Functionen
dc.subjectImmune Regulationen
dc.titleImmune function in hypopituitarism; time to reconsider?en
dc.typeArticleen
dc.contributor.departmentDept of Endocrinology, Christie Hospital, Manchester, UK.en
dc.identifier.journalClinical Endocrinologyen
html.description.abstractAbstract Hypopituitarism is not currently considered as a potential cause of immune disruption in humans. Accumulating data from in-vitro and animal models support a role for the pituitary gland in immune regulation. Furthermore the increased mortality risk noted in patients with adult hypopituitarism remains poorly explained and immune dysfunction could conceivably contribute to this observation. In a recent issue of Clinical & Experimental Immunology we presented new data relating to immune status in adults with treated, severe hypopituitarism. We observed humoral immune deficiency in a significant proportion, despite stable pituitary replacement, including growth hormone (GH). This was especially evident in those with low pre-treatment IGF-I levels and appeared independent of anticonvulsant use or corticosteroid replacement. These observations require substantiation with future studies. In this short review we summarise existing data relating to the effects of pituitary hormones on immune function, and discuss potential clinical implications surrounding the hypothesis of immune dysregulation in severe hypopituitarism.


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